CAS 138890-62-7

Brinzolamide

Description:

Brinzolamide is a carbonic anhydrase inhibitor primarily used in the treatment of elevated intraocular pressure in conditions such as glaucoma and ocular hypertension. It is a sulfonamide derivative, characterized by its ability to inhibit the enzyme carbonic anhydrase, which plays a crucial role in the production of aqueous humor in the eye. This inhibition leads to a decrease in fluid production, thereby lowering intraocular pressure. Brinzolamide is typically administered as an ophthalmic suspension, and its formulation often includes stabilizers and preservatives to enhance its efficacy and shelf life. The compound is known for its relatively low systemic absorption when applied topically, which minimizes potential side effects. In terms of solubility, brinzolamide is more soluble in organic solvents than in water, which influences its formulation and delivery methods. Overall, brinzolamide is an important therapeutic agent in ophthalmology, providing a non-invasive option for managing intraocular pressure.

Formula: C₁₂H₂₁N₃O₅S₃

InChI: InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1

InChI key: InChIKey=HCRKCZRJWPKOAR-JTQLQIEISA-N

SMILES: O=S1(=O)C2=C([C@@H](NCC)CN1CCCOC)C=C(S(N)(=O)=O)S2

Synonyms:

• (4R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-Dioxide
• (4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
• (5R)-5-Ethylamino-3-(3-methoxypropyl)-2,2-dioxo-2λ⁶,9-dithia-3-azabicyclo[4.3.0]nona-7,10-diene-8-sulfonamide
• (R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
• 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide, 4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-, 1,1-dioxide
• 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide, 4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-, 1,1-dioxide, (4R)-
• 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide, 4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-, 1,1-dioxide, (R)-
• 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide, 4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-, 1,1-dioxide, (S)-
• Al 4862
• Birnzolamide
• Brinlolamide
• (5R)-5-Ethylamino-3-(3-methoxypropyl)-2,2-dioxo-2λ6,9-dithia-3-azabicyclo[4.3.0]nona-7,10-diene-8-sulfonamide

Brinzolamide

CAS: 138890-62-7

Formula: C₁₂H₂₁N₃O₅S₃

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 383.50

Ref: 3B-B4258

Brinzolamide

CAS: 138890-62-7

Sulfonamides used as drugs

Formula: C₁₂H₂₁N₃O₅S₃

Color and Shape: White Off-White Powder

Molecular weight: 383.06433

Ref: 45-1076363

2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide, 4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-, 1,1-dioxide, (4R)-

CAS: 138890-62-7

Formula: C₁₂H₂₁N₃O₅S₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 383.5072

Ref: IN-DA0019S5

Brinzolamide

CAS: 138890-62-7

Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor.

Formula: C₁₂H₂₁N₃O₅S₃

Purity: 99.84% - >99.99%

Color and Shape: Crystalline Solid

Molecular weight: 383.51

Ref: TM-T0142

Brinzolamide

CAS: 138890-62-7

Brinzolamide

Purity: 99%

Molecular weight: 383.51g/mol

Ref: 54-OR1024589

Brinzolamide

CAS: 138890-62-7

Formula: C₁₂H₂₁N₃O₅S₃

Color and Shape: White To Off-White Solid

Molecular weight: 383.50

Ref: 4Z-B-201

Brinzolamide

CAS: 138890-62-7

Brinzolamide

Purity: ≥98%

Molecular weight: 383.51g/mol

Ref: 54-BUP11935

Brinzolamide

Controlled Product

CAS: 138890-62-7

Formula: C₁₂H₂₁N₃O₅S₃

Color and Shape: Neat

Molecular weight: 383.51

Ref: 86-MM1300.00

Brinzolamide

CAS: 138890-62-7

Formula: C₁₂H₂₁N₃O₅S₃

Molecular weight: 383.51

Ref: 7W-GP5583

Brinzolamide Impurity 9

CAS: 138890-62-7

Formula: C₂₁H₂₈N₂O₉S₄

Color and Shape: White To Off-White Solid

Molecular weight: 580.70

Ref: 4Z-B-2019

Brinzolamide

Controlled Product

CAS: 138890-62-7

Applications Carbonic anhydrase inhibitor. Antiglaucoma agent.
References Silver, L.H., et al.: Am. J. Ophthalmol., 126, 400 (1998), Davies, N., et al.: Clin. Exp. Pharmacol. Physiol., 27, 558 (2000), Stave, J., et al.: Ophthalmologe, 99, 276 (2002),

Formula: C₁₂H₂₁N₃O₅S₃

Color and Shape: Neat

Molecular weight: 383.51

Ref: TR-B677601

Brinzolamide

CAS: 138890-62-7

Inhibitor of carbonic anhydrase

Formula: C₁₂H₂₁N₃O₅S₃

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 383.51 g/mol

Ref: 3D-FB29475

Brinzolamide - Bio-X ™

CAS: 138890-62-7

Brinzolamide is a carbonic anhydrase inhibitor this is used for the treatment of ocular hypertension and glaucoma. Inhibition of carbonic anhydrase slows the formation of bicarbonate ions and as a result of this, it slows fluid flow in the eye, lowering the intraocular pressure. It has a high lipophilicity to enable diffusion across the blood-retinal barrier.

Formula: C₁₂H₂₁N₃O₅S₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 383.51 g/mol

Ref: 3D-BB164262

BRINZOLAMIDE

CAS: 138890-62-7

Formula: C₁₂H₂₁N₃O₅S₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 383.5

Ref: 10-F387702