CAS 138900-22-8

5-Chloro-1-(4-fluorophenyl)-1H-indole

Description:

5-Chloro-1-(4-fluorophenyl)-1H-indole is a chemical compound characterized by its indole structure, which consists of a fused benzene and pyrrole ring. The presence of a chlorine atom at the 5-position and a fluorophenyl group at the 1-position contributes to its unique chemical properties. This compound is typically a solid at room temperature and may exhibit moderate solubility in organic solvents, depending on the specific conditions. It is often studied for its potential biological activities, particularly in medicinal chemistry, where modifications to the indole core can influence pharmacological properties. The presence of halogen substituents like chlorine and fluorine can enhance lipophilicity and affect the compound's interaction with biological targets. Additionally, 5-Chloro-1-(4-fluorophenyl)-1H-indole may undergo various chemical reactions, including electrophilic substitutions and nucleophilic attacks, making it a versatile building block in organic synthesis. Safety data should be consulted for handling and storage, as with any chemical substance, to ensure proper laboratory practices.

Formula: C₁₄H₉ClFN

InChI: InChI=1/C14H9ClFN/c15-11-1-6-14-10(9-11)7-8-17(14)13-4-2-12(16)3-5-13/h1-9H

InChI key: InChIKey=JYEKQDWSLSXYTJ-UHFFFAOYSA-N

SMILES: ClC=1C=C2C(N(C=C2)C3=CC=C(F)C=C3)=CC1

Synonyms:

• 1-(4-Fluorophenyl)-5-chloroindole
• 1H-indole, 5-chloro-1-(4-fluorophenyl)-
• 5-Chloro-1-(4-fluorophenyl)-1H-indole
• 5-Chloro-1-(4-fluorophenyl)indole
• 5-CHLORO-1-(4-FLUORO-PHENYL)-1H-INDOLE
• Sertindole Impurity 1

1H-INDOLE, 5-CHLORO-1-(4-FLUOROPHENYL)-

CAS: 138900-22-8

Formula: C₁₄H₉ClFN

Purity: 95%

Color and Shape: Solid

Molecular weight: 245.6794

Ref: IN-DA0019SW

Sertindole Impurity 1

CAS: 138900-22-8

Formula: C₁₄H₉ClFN

Molecular weight: 245.68

Ref: 4Z-S-150003

5-Chloro-1-(4-fluorophenyl)indole

Controlled Product

CAS: 138900-22-8

Applications Can be used in the preparation of serotoninergic S2 antagonists.
References Andersen, K. et al.: J. Med. Chem. 39, 3723(1996); Perregaard, J. et al.: J. Med. Chem. 35, 1092(1992)

Formula: C₁₄H₉ClFN

Color and Shape: Neat

Molecular weight: 245.68

Ref: TR-C366370