CAS 139023-58-8

ManuMycin B

Description:

ManuMycin B is a natural product belonging to the class of antibiotics, specifically a member of the manumycin family, which are known for their antibacterial and antifungal properties. It is produced by certain strains of the bacterium *Streptomyces*, which are renowned for their ability to synthesize a wide variety of bioactive compounds. The chemical structure of ManuMycin B features a complex arrangement of rings and functional groups that contribute to its biological activity. This compound exhibits potent activity against various Gram-positive bacteria, making it a subject of interest in pharmaceutical research for potential therapeutic applications. Additionally, ManuMycin B has been studied for its ability to inhibit specific enzymes and pathways in microbial cells, which can lead to cell death. Its unique mechanism of action and structural characteristics make it a valuable candidate for further investigation in the development of new antimicrobial agents, particularly in the face of rising antibiotic resistance.

Formula: C₂₈H₃₄N₂O₇

Synonyms:

• ManuMycin B
• (2E,4R)-N-[(1S,5S,6R)-5-Hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxo-1,3,5-heptatrien-1-yl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2,4-dimethyl-2-octenamide

Manumycin B

CAS: 139023-58-8

Manumycin B is an antibiotic with antitumor properties. It acts as an inhibitor of acetylcholinesterase (AChE) with an IC50 value of 15 mM.

Formula: C₂₈H₃₄N₂O₇

Color and Shape: Solid

Molecular weight: 510.58

Ref: TM-T88431

Manumycin B

CAS: 139023-58-8

Formula: C₂₈H₃₄N₂O₇

Molecular weight: 510.6

Ref: 7W-GA7050

Manumycin B

CAS: 139023-58-8

Manumycin B is a polyketide antibiotic, which is a secondary metabolite isolated from certain Streptomyces species. This compound is known for its complex biosynthetic origin involving iterative cycles of polyketide synthesis, leading to its characteristic structure. The mode of action of Manumycin B primarily involves the inhibition of farnesyltransferase, an enzyme critical for the post-translational modification of various proteins, including the Ras family of GTPases. By hindering this enzyme, Manumycin B disrupts the signaling pathways that are essential for tumor cell growth and proliferation.

Formula: C₂₈H₃₄N₂O₇

Purity: Min. 95%

Molecular weight: 510.6 g/mol

Ref: 3D-PFA02358