CAS 139026-66-7

JMV 449

Description:

JMV 449, with the CAS number 139026-66-7, is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its potential therapeutic applications. It is characterized by its specific molecular structure, which includes various functional groups that contribute to its biological activity. The compound has been studied for its interactions with biological targets, making it of interest in drug discovery and development. Its solubility, stability, and reactivity are important factors that influence its efficacy and safety profile. Additionally, JMV 449 may exhibit unique pharmacokinetic properties, affecting its absorption, distribution, metabolism, and excretion in biological systems. Research into this compound may also explore its mechanism of action, potential side effects, and therapeutic windows. Overall, JMV 449 represents a significant area of study within pharmaceutical chemistry, with ongoing research aimed at elucidating its full potential and applications in treating various medical conditions.

Formula: C₃₈H₆₆N₈O₇

InChI: InChI=1/C38H66N8O7/c1-5-25(4)33(36(50)44-31(38(52)53)21-24(2)3)45-34(48)30(22-26-14-16-28(47)17-15-26)43-35(49)32-13-10-20-46(32)37(51)29(12-7-9-19-40)42-23-27(41)11-6-8-18-39/h14-17,24-25,27,29-33,42,47H,5-13,18-23,39-41H2,1-4H3,(H,43,49)(H,44,50)(H,45,48)(H,52,53)/t25-,27-,29-,30-,31-,32-,33-/m0/s1

SMILES: CC[C@H](C)[C@@H](C(=N[C@@H](CC(C)C)C(=O)O)O)N=C([C@H](Cc1ccc(cc1)O)N=C([C@@H]1CCCN1C(=O)[C@H](CCCCN)NC[C@H](CCCCN)N)O)O

Synonyms:

• [Lys8-Psi(Ch2Nh)-Lys9]Neurotensin (8-13)
• (Lys8-(R)-Lys9)-Neurotensin (8-13)
• Lys-Psi(Ch2Nh)-Lys-Pro-Tyr-Ile-Leu
• H-Lys-(R)-Lys-Pro-Tyr-Ile-Leu-Oh
• M.W. 746.96 C38H66N8O7
• N~2~-[(2S)-2,6-diaminohexyl]-L-lysyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine

JMV 449

CAS: 139026-66-7

Potent neurotensin agonist; IC50=0.15 nM, EC50=1.9 nM. Causes hypothermia, neuroprotection, analgesia in mice.

Formula: C₃₈H₆₆N₈O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 746.96

Ref: TM-TP2012

(Lys8-psi(CH2NH)Lys9)-Neurotensin (8-13)

CAS: 139026-66-7

Neurotensin (NT) is a neuropeptide that is derived from the prepro-NT gene. It binds to the neurotensin receptor 1 (NTSR1) and has been shown to regulate intestinal motility, as well as function as an adjuvant therapy for enteric diseases. Neurotensin has been shown to be neuroprotective against dopamine toxicity in cell cultures, and could be used in cancer therapy. The profile of neurotensin has been studied in clinical trials for metastatic breast cancer and other cancers. Neurotensin does not have any significant safety issues, although it can cause neuronal death when administered intracerebroventricularly.

Formula: C₃₈H₆₆N₈O₇

Purity: Min. 95%

Molecular weight: 746.98 g/mol

Ref: 3D-FL110306