CAS 1390637-82-7

PF-04981517

CAS: 1390637-82-7

Formula: C₂₆H₃₂N₈

Purity: 98%

Molecular weight: 456.5859

Ref: IN-DA009EB7

PF-4981517

CAS: 1390637-82-7

PF-4981517

Purity: ≥98%

Molecular weight: 456.59g/mol

Ref: 54-BUP02214

PF-4981517

CAS: 1390637-82-7

PF-4981517: potent, specific CYP3A4 inhibitor. IC50: CYP3A4 (0.03μM), CYP3A5 (17μM), CYP3A7 (71μM). Helps differentiate CYP3A4/5 in drug metabolism.

Formula: C₂₆H₃₂N₈

Purity: 99.83%

Color and Shape: Solid

Molecular weight: 456.59

Ref: TM-T21548

PF-4981517

CAS: 1390637-82-7

PF-4981517 is a potent and selective inhibitor of human cytochrome P450 3A4 (CYP3A4) and CYP3A5. It has been shown to inhibit CYP3A4, CYP3A5, and other drug metabolizing enzymes in both humans and animal models. PF-4981517 inhibits renal cell cancer in vivo by inhibiting the transcriptional activation of gene markers associated with tumorigenesis. This agent also inhibits the expression of nuclear receptors that are involved in inflammatory processes and carcinogenesis. PF-4981517 potently inhibits the activity of a number of human cytochrome P450 enzymes, including CYP2C9, CYP2C19, CYP1A2, and CYP2D6.

Formula: C₂₆H₃₂N₈

Purity: Min. 95%

Molecular weight: 456.59 g/mol

Ref: 3D-QFC63782