CAS 139079-39-3

7-Hydroxyquetiapine

Description:

7-Hydroxyquetiapine is a chemical compound that is a derivative of quetiapine, an atypical antipsychotic medication primarily used to treat schizophrenia and bipolar disorder. This substance is characterized by the presence of a hydroxyl group at the seventh position of the quetiapine structure, which influences its pharmacological properties. It is known to exhibit affinity for various neurotransmitter receptors, including serotonin and dopamine receptors, contributing to its potential therapeutic effects. The compound is typically found in a solid form and is soluble in organic solvents, with limited solubility in water. Its molecular structure includes a dibenzothiazepine core, which is common among antipsychotic agents. Research indicates that 7-Hydroxyquetiapine may play a role in the drug's efficacy and side effect profile, making it a subject of interest in pharmacological studies. As with many pharmaceutical compounds, understanding its characteristics is crucial for evaluating its therapeutic potential and safety in clinical applications.

Formula: C₂₁H₂₅N₃O₃S

InChI: InChI=1S/C21H25N3O3S/c25-12-14-27-13-11-23-7-9-24(10-8-23)21-17-3-1-2-4-19(17)28-20-15-16(26)5-6-18(20)22-21/h1-6,15,25-26H,7-14H2

InChI key: InChIKey=VEGVCHRFYPFJFO-UHFFFAOYSA-N

SMILES: C(COCCO)N1CCN(C=2C=3C(SC=4C(N2)=CC=C(O)C4)=CC=CC3)CC1

Synonyms:

• 11-[4-[2-(2-Hydroxyethoxy)ethyl]-1-piperazinyl]-dibenzo[b,f][1,4]thiazepin-7-ol
• 11-{4-[2-(2-Hydroxyethoxy)Ethyl]Piperazin-1-Yl}Dibenzo[B,F][1,4]Thiazepin-7-Ol
• 2-(2-(7-Hydroxy-4-Dibenzo(B,F)(1,4)Thiazepine-11-Yl-1-Piperazinyl)Ethoxy)Ethanol
• 7-Hydroxyquetiapine
• Dibenzo[b,f][1,4]thiazepin-7-ol, 11-[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]-
• Ici 214227
• Ici214227

7-Hydroxyquetiapine

CAS: 139079-39-3

Formula: C₂₁H₂₅N₃O₃S

Color and Shape: Solid

Molecular weight: 399.5065

Ref: IN-DA001A5C

7-Hydroxy Quetiapine Hemifumarate

CAS: 139079-39-3

Formula: C₂₁H₂₅N₃O₃S·5C₄H₄O₄

Color and Shape: White To Off-White Solid

Molecular weight: 399.51 0.5*116.07

Ref: 4Z-Q-013

7-Hydroxy Quetiapine-d4 Hemifumarate

CAS: 139079-39-3

Formula: C₂₁H₂₁D₄N₃O₃S·5C₄H₄O₄

Color and Shape: White To Off-White Solid

Molecular weight: 403.53 0.5*116.07

Ref: 4Z-Q-014

7-Hydroxy Quetiapine

Controlled Product

CAS: 139079-39-3

Stability Hygroscopic
Applications A metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic.
References Newton, D., et al.: Drug Metab. Dispos., 23, 154 (1995), Tanaka, E., et al.: J. Clin. Pharm. Ther., 24, 7 (1999)

Formula: C₂₁H₂₅N₃O₃S

Color and Shape: White

Molecular weight: 399.51

Ref: TR-H953225

7-Hydroxy Quetiapine (1.0 mg/mL in Methanol)

Controlled Product

CAS: 139079-39-3

Formula: C₂₁H₂₅N₃O₃S

Color and Shape: Single Solution

Molecular weight: 399.51

Ref: TR-KIT1245

7-Hydroxy Quetiapine

CAS: 139079-39-3

Formula: C₂₁H₂₅N₃O₃S

Molecular weight: 399.51

Ref: ST-EA-CP-Q1070