CAS 13909-09-6

Semustine

Description:

Semustine, also known as methyl-CCNU, is a synthetic alkylating agent primarily used in the treatment of certain types of cancer, particularly brain tumors and lymphomas. It belongs to the class of nitrosoureas, which are known for their ability to cross the blood-brain barrier, making them effective for central nervous system malignancies. Semustine functions by introducing alkyl groups into DNA, leading to cross-linking and subsequent disruption of DNA replication and transcription, ultimately inducing cell death. The compound is typically administered orally and has a relatively long half-life, allowing for sustained therapeutic effects. Common side effects associated with Semustine include myelosuppression, gastrointestinal disturbances, and potential hepatotoxicity. Due to its mechanism of action, it is often used in combination with other chemotherapeutic agents to enhance efficacy. As with all chemotherapeutic agents, careful monitoring of patient response and side effects is essential during treatment.

Formula: C₁₀H₁₈ClN₃O₂

InChI: InChI=1S/C10H18ClN3O2/c1-8-2-4-9(5-3-8)12-10(15)14(13-16)7-6-11/h8-9H,2-7H2,1H3,(H,12,15)

InChI key: InChIKey=FVLVBPDQNARYJU-UHFFFAOYSA-N

SMILES: N(C(N(CCCl)N=O)=O)C1CCC(C)CC1

Synonyms:

• 1-(2-Chloroethyl)-1-Formyl-3-(4-Methylcyclohexyl)Urea
• 1-(2-Chloroethyl)-3-(4-Methylcyclohexyl)-1-Nitrosourea
• 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosurea
• 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)nitrosourea
• Icig 1110
• Me-CCNU
• Methyl lomustine
• Methyl-CCNU
• N-(2-Chloroethyl)-N′-(4-methylcyclohexyl)-N-nitrosourea
• N′-(4-Methylcyclohexyl)-N-(2-chloroethyl)-N-nitrosourea
• Urea, 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitroso-
• Urea, N-(2-chloroethyl)-N′-(4-methylcyclohexyl)-N-nitroso-

N-(2-Chloroethyl)-N′-(4-methylcyclohexyl)-N-nitrosourea

CAS: 13909-09-6

Formula: C₁₀H₁₈ClN₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 247.7218

Ref: IN-DA001A8N

Semustine

CAS: 13909-09-6

Semustine

Purity: ≥98%

Molecular weight: 247.72g/mol

Ref: 54-BUP09190

Semustine

CAS: 13909-09-6

Formula: C₁₁H₁₉ClN₂O₂

Molecular weight: 246.73

Ref: 7W-GP4543

Semustine

CAS: 13909-09-6

Semustine, a DNA alkylating agent, is a cancer chemotherapy compound that is nephrotoxic in patients with malignant melanoma receiving adjuvant chemotherapy for

Formula: C₁₀H₁₈ClN₃O₂

Purity: 99.70%

Color and Shape: Light Yellow Powder

Molecular weight: 247.72

Ref: TM-T16871

Semustine

Controlled Product

CAS: 13909-09-6

Applications Semustine is an alkylating agent and interstrand DNA cross linker. Anti-cancer chemotherapeutic agents, which are used in the treatment of different types of cancer such as brain tumors, resistant Hodgkin’s disease, lung cancer and malignant melanoma.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Agarwal, S., et al.: J. Photochem. Photobiol. B, Biol., 166, 1-11 (2017)

Formula: C₁₀H₁₈ClN₃O₂

Color and Shape: Neat

Molecular weight: 247.722

Ref: TR-S258205