CAS 1391107-57-5

1H-Pyrrole-3-carboxylic acid, 5-(4-chlorophenyl)-4-[3-[4-[4-[[[4-[[(1R)-3-(4-hydroxy-1-piperidinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]amino]phenyl]-1-piperazinyl]phenyl]-2-methyl-1-(1-methylethyl)-

Description:

1H-Pyrrole-3-carboxylic acid, 5-(4-chlorophenyl)-4-[3-[4-[4-[[[4-[[(1R)-3-(4-hydroxy-1-piperidinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]amino]phenyl]-1-piperazinyl]phenyl]-2-methyl-1-(1-methylethyl)- is a complex organic compound characterized by its multi-functional structure, which includes a pyrrole ring, various aromatic systems, and multiple substituents that contribute to its chemical properties. The presence of a carboxylic acid group indicates potential for hydrogen bonding and reactivity in acid-base chemistry. The chlorophenyl and trifluoromethyl groups enhance its lipophilicity and may influence its biological activity. Additionally, the compound contains piperidine and piperazine moieties, which are often associated with pharmacological properties, suggesting potential applications in medicinal chemistry. Its intricate structure may also lead to specific interactions with biological targets, making it of interest in drug development. Overall, this compound exemplifies the complexity and diversity of modern organic molecules used in various scientific fields.

Formula: C₅₃H₅₈ClF₃N₆O₇S₃

Synonyms:

• 1H-Pyrrole-3-carboxylic acid, 5-(4-chlorophenyl)-4-[3-[4-[4-[[[4-[[(1R)-3-(4-hydroxy-1-piperidinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]amino]phenyl]-1-piperazinyl]phenyl]-2-methyl-1-(1-methylethyl)-

BM-962

CAS: 1391107-57-5

BM-962 (Compound 31) is a potent small-molecule inhibitor with an IC50 value of 4 nM (Ki=0.8 nM) for Bcl-2 and an IC50 of 3.9 nM (Ki<1 nM) for Bcl-xL. It inhibits H1417 and H146 cell lines with IC50 values of 9 and 13 nM, respectively, and shows potential for use in cancer research.

Formula: C₅₃H₅₈ClF₃N₆O₇S₃

Color and Shape: Solid

Molecular weight: 1079.71

Ref: TM-T203282