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CAS 139133-26-9

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Lexipafant

Description:
Lexipafant, with the CAS number 139133-26-9, is a chemical compound that functions primarily as a selective antagonist of the platelet-activating factor (PAF) receptor. It is known for its potential therapeutic applications, particularly in the context of inflammatory conditions and certain cardiovascular diseases. Lexipafant exhibits properties that may help modulate inflammatory responses, making it a subject of interest in research related to conditions such as acute lung injury and sepsis. The compound is characterized by its ability to inhibit the biological effects of PAF, which is a potent phospholipid mediator involved in various physiological and pathological processes. Lexipafant's pharmacological profile includes its ability to reduce vascular permeability and leukocyte activation, contributing to its anti-inflammatory effects. While it has shown promise in preclinical and clinical studies, further research is necessary to fully understand its efficacy and safety in various therapeutic contexts.
Formula:C23H30N4O4S
InChI:InChI=1S/C23H30N4O4S/c1-6-31-23(28)22(13-16(2)3)26(5)32(29,30)19-9-7-18(8-10-19)15-27-17(4)25-20-14-24-12-11-21(20)27/h7-12,14,16,22H,6,13,15H2,1-5H3/t22-/m0/s1
InChI key:InChIKey=AQRXDPFOYJSPMP-QFIPXVFZSA-N
SMILES:C(N1C=2C(N=C1C)=CN=CC2)C3=CC=C(S(N([C@H](C(OCC)=O)CC(C)C)C)(=O)=O)C=C3
Synonyms:
  • 1H-Imidazo[4,5-c]pyridine, L-leucine deriv.
  • Lexipafant
  • N-Methyl-N-[[α-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)-p-tolyl]sulfonyl]-L-leucine ethyl ester
  • DO 6
  • L-Leucine, N-methyl-N-[[4-[(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]phenyl]sulfonyl]-, ethyl ester
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