CAS 1392-60-5

Mycosubtiline

Description:

Mycosubtiline, with the CAS number 1392-60-5, is a naturally occurring antibiotic produced by certain strains of the bacterium Bacillus subtilis. It belongs to the class of compounds known as lipopeptides, which are characterized by their unique structure that includes a lipid tail and a peptide portion. Mycosubtiline exhibits antimicrobial properties, particularly against a range of Gram-positive bacteria and some fungi, making it of interest in both agricultural and pharmaceutical applications. The compound functions by disrupting bacterial cell membrane integrity, leading to cell lysis. In addition to its antibacterial activity, mycosubtiline may also have potential as a biocontrol agent in agriculture, helping to protect crops from pathogenic microorganisms. Its stability and efficacy in various environmental conditions further enhance its utility. As with many antibiotics, the development of resistance is a concern, necessitating ongoing research into its mechanisms of action and potential applications. Overall, mycosubtiline represents a significant compound in the study of natural antibiotics and their applications in health and agriculture.

Formula: C₃₇H₅₁N₁₂O₁₄R

InChI: InChI=1/C55H86N14O16/c1-3-30(2)13-10-8-6-4-5-7-9-11-14-32-24-47(77)62-36(25-43(57)73)50(80)63-34(20-21-42(56)72)55(85)69-22-12-15-41(69)54(84)67-35(23-31-16-18-33(71)19-17-31)49(79)64-38(27-45(59)75)51(81)65-39(28-46(60)76)52(82)68-40(29-70)53(83)66-37(26-44(58)74)48(78)61-32/h16-19,30,32,34-41,70-71H,3-15,20-29H2,1-2H3,(H2,56,72)(H2,57,73)(H2,58,74)(H2,59,75)(H2,60,76)(H,61,78)(H,62,77)(H,63,80)(H,64,79)(H,65,81)(H,66,83)(H,67,84)(H,68,82)/t30?,32?,34-,35+,36-,37-,38+,39+,40+,41-/m0/s1

Synonyms:

• Mycosubtilin (9CI)
• Mycosubtilin
• 3-[(3R,6R,9R,12R,15S,22S,25S,30aS)-6,9,15,22-tetrakis(2-amino-2-oxoethyl)-3-(4-hydroxybenzyl)-12-(hydroxymethyl)-18-(11-methyltridecyl)-1,4,7,10,13,16,20,23,26-nonaoxotriacontahydropyrrolo[1,2-g][1,4,7,10,13,16,19,22,25]nonaazacyclooctacosin-25-yl]propanamide
• C12030
• Mycosubtiline
• Pyrrolo(1,2-g)(1,4,7,10,13,16,19,22,25)nonaazacyclooctacosine, cyclic peptide deriv.

Mycosubtilin

CAS: 1392-60-5

Mycosubtilin is a potent antifungal lipopeptide, which is a secondary metabolite produced by the bacterium Bacillus subtilis. It is characterized by its ability to disrupt fungal cell membranes, leading to cell lysis and eventual death of the fungus. This mode of action is attributed to its amphiphilic structure, which allows it to integrate into the lipid bilayers of fungal cells, compromising the integrity of the membrane and altering its permeability.Mycosubtilin finds applications in various scientific and agricultural fields due to its efficacy against a broad spectrum of fungal pathogens. It is particularly useful in plant disease management, where it plays a role in biocontrol strategies against phytopathogenic fungi. Additionally, its antifungal properties make it a subject of interest in pharmaceutical research, where it is investigated for potential therapeutic applications in combating fungal infections. Researchers also explore Mycosubtilin as a model compound to understand lipopeptide interactions with membranes, contributing to the broader knowledge of antimicrobial agents.

Ref: 3D-BM161386