CAS 1392275-56-7

Tenofovir alafenamide fumarate

Description:

Tenofovir alafenamide fumarate (TAF) is an antiretroviral medication primarily used in the treatment of HIV and hepatitis B infections. It is a prodrug of tenofovir, which means it is metabolized in the body to release the active form, tenofovir. TAF is characterized by its improved pharmacokinetic profile compared to its predecessor, tenofovir disoproxil fumarate (TDF), allowing for lower dosing and reduced renal and bone toxicity. The substance is typically administered orally and is often combined with other antiretroviral agents in fixed-dose combinations to enhance efficacy and adherence. TAF is a nucleotide reverse transcriptase inhibitor (NRTI) that works by inhibiting the reverse transcriptase enzyme, thereby preventing viral replication. Its chemical structure includes a fumarate salt, which contributes to its stability and solubility. Overall, TAF represents a significant advancement in HIV therapy, providing effective viral suppression with a more favorable safety profile.

Formula: C₂₁H₂₉N₆O₅PC₄H₄O₄

SMILES: C([C@H](OCP(OC1=CC=CC=C1)(N[C@H](C(OC(C)C)=O)C)=O)C)N2C=3C(N=C2)=C(N)N=CN3.C(=C/C(O)=O)\C(O)=O

Synonyms:

• GS 7340-03
• Tenofovir alafenamide hemifumarate
• L-Alanine, N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (2:1)
• Tenofovir alafenamide fumarate
• Tenofovir Alafenamide Fumarate

L-Alanine, N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (2:1)

CAS: 1392275-56-7

Formula: C₄₆H₆₂N₁₂O₁₄P₂

Purity: %

Color and Shape: Solid

Molecular weight: 1069.0040

Ref: IN-DA001AJ3

Tenofovir Alafenamide Fumarate

CAS: 1392275-56-7

Tenofovir Alafenamide Fumarate

Purity: 99%

Molecular weight: 1069.02g/mol

Ref: 54-OR1024948

Tenofovir alafenamide hemifumarate

CAS: 1392275-56-7

Tenofovir alafenamide hemifumarate

Purity: ≥98%

Molecular weight: 534.51g/mol

Ref: 54-BUP13343

Tenofovir alafenamide hemifumarate

CAS: 1392275-56-7

Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir.

Formula: C₂₁H₂₉N₆O₅PC₄H₄O₄

Purity: 99.33% - 99.96%

Color and Shape: Solid

Molecular weight: 534.51

Ref: TM-T7282

1-Methylethyl N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinoyl)-L-alaninate

CAS: 1392275-56-7

Tenofovir is a nucleoside analog reverse transcriptase inhibitor that binds to the RNA-dependent polymerase. This compound is used in combination with other antiviral agents for the treatment of HIV-1 infection and for prophylaxis against HIV-1 infection. Tenofovir has been shown to be effective against infections caused by strains of HIV-1, such as the drug resistant virus. Tenofovir is absorbed rapidly after oral administration, with a bioavailability of over 80%. The prodrug fumarate is hydrolyzed to tenofovir in vivo and this conversion occurs more efficiently in acidic conditions. Alafenamide, a prodrug of tenofovir, has been approved by the FDA as an alternative to tenofovir disoproxil fumarate (TDF) for the treatment of HIV-1 infection. Alafenamide is an acyclic nucleoside phosphonate that inhibits viral replication by inhibiting reverse

Formula: C₄₆H₆₂N₁₂O₁₄P₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,069 g/mol

Ref: 3D-FM75154