CAS 1392399-03-9

BIX 01294

Description:

BIX 01294 is a small molecule inhibitor primarily known for its role in epigenetic research, specifically as a selective inhibitor of the histone methyltransferase G9a and GLP (G9a-like protein). It is characterized by its ability to inhibit the methylation of lysine 9 on histone H3, which is a critical modification associated with gene repression. This compound has garnered attention for its potential applications in cancer research and stem cell biology, as it can influence gene expression patterns and cellular differentiation. BIX 01294 is typically utilized in various biological assays to study the effects of histone methylation on cellular processes. Its chemical structure includes specific functional groups that contribute to its binding affinity and selectivity for the target enzymes. As with many small molecule inhibitors, the effectiveness and specificity of BIX 01294 can vary depending on the cellular context and the presence of other epigenetic modifiers. Researchers continue to explore its therapeutic potential and mechanisms of action in various biological systems.

BIX 01294

CAS: 1392399-03-9

Formula: C₂₈H₄₁Cl₃N₆O₂

Purity: %

Color and Shape: Solid

Molecular weight: 600.0231

Ref: IN-DA009F63

BIX-01294 trihydrochloride

CAS: 1392399-03-9

BIX-01294 trihydrochloride

Purity: ≥98%

Molecular weight: 600.02g/mol

Ref: 54-BUP12099

BIX 01294 trihydrochloride

CAS: 1392399-03-9

Formula: C₂₈H₃₈N₆O₂·3HCl

Molecular weight: 600

Ref: 7W-GL6636

BIX-01294 trihydrochloride

CAS: 1392399-03-9

BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.

Formula: C₂₈H₃₈N₆O₂·3HCl

Purity: 99.41% - 99.95%

Color and Shape: Solid

Molecular weight: 600.02

Ref: TM-T1959

BIX 01294 Trihydrochloride

Controlled Product

CAS: 1392399-03-9

Applications BIX 01294 Trihydrochloride is a G9a-like protein and G9a histone lysine methyltransferase (HMTase) inhibitor that H3K9me2 chromatin levels modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro.
References Kubicek, S. et al.: Mol. Cell., 25, 473 (2007); Huangfu, D et al.: Nat. Biotechnol., 26, 795 (2008); Chang, Y. et al.: Bat. Struct. Mol. Biol., 16, 312 (2009);

Formula: C₂₈H₃₈N₆O₂·3ClH

Color and Shape: Neat

Molecular weight: 600.023

Ref: TR-B591600

BIX 01294

CAS: 1392399-03-9

Inhibitor of histone methyltransferase G9a

Formula: C₂₈H₃₈N₆O₂·3HCl

Purity: Min. 95%

Molecular weight: 600.02 g/mol

Ref: 3D-BB162787