CAS 139290-65-6

(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL

Description:

(R)-(+)-Alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluoro-phenyl)ethyl]-4-piperidine methanol, with CAS number 139290-65-6, is a chemical compound characterized by its complex molecular structure, which includes a piperidine ring and multiple aromatic substituents. This compound is typically classified as a piperidine derivative and may exhibit properties associated with central nervous system activity, given the presence of the piperidine moiety. The presence of the fluorine atom in the phenyl group can influence its pharmacological properties, potentially enhancing lipophilicity and altering receptor binding affinity. The methanol group suggests the potential for hydrogen bonding, which may affect solubility and reactivity. Additionally, the stereochemistry indicated by the (R)-configuration implies specific spatial arrangements that can significantly impact biological activity and interactions with biological targets. Overall, this compound's unique structural features suggest potential applications in medicinal chemistry, particularly in the development of therapeutic agents. However, detailed studies would be necessary to fully elucidate its properties and potential uses.

Formula: C₂₂H₂₈FNO₃

InChI: InChI=1/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3

InChI key: InChIKey=HXTGXYRHXAGCFP-OAQYLSRUSA-N

SMILES: [C@H](O)(C1=C(OC)C(OC)=CC=C1)C2CCN(CCC3=CC=C(F)C=C3)CC2

Synonyms:

• (+)-Mdl 100907
• (+)-a-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
• (2,3-Dimethoxyphenyl){1-[2-(4-Fluorophenyl)Ethyl]Piperidin-4-Yl}Methanol
• (R)-(2,3-Dimethoxyphenyl)-[1-[2-(4-fluorophenyl)ethyl]piperidin-4-yl]methanol
• (aR)-a-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
• 4-Piperidinemethanol, 1-[2-(4-Fluorophenyl)Ethyl]-Alpha-(2,3-Dimethoxyphenyl)-, (Alphar)
• 4-Piperidinemethanol, α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-, (R)-
• 4-Piperidinemethanol, α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-, (αR)-
• M 100907
• Mdl100907
• R-Mdl 100907
• Volinanserin
• (R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL
• MDL-100907(Volinanserin)
• MDL100907 tartrate salt
• Volinanserin Hydrochloride Salt
• (aR)-a-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol Hydrochloride
• (R)-(+)-(-(2,3-Dimethoxyphenyl)-1-[2-(4-fluoro-phenyl)ethyl]-4-piperidine methanol
• MDL100907-L-tartrate
• (R)-(2,3-dimethoxyphenyl)(1-(4-fluorophenethyl)piperidin-4-yl)methanol
• (+)-a-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol Hydrochloride
• 4-Piperidinemethanol, 1-[2-(4-fluorophenyl)ethyl]-(-(2,3-dimethoxyphenyl)-, ((R), (R,R)-tartrate
• 4-Piperidinemethanol, 1-[2-(4-fluorophenyl)ethyl]-(-(2,3-dimethoxyphenyl)-, ((R)
• (+)-α-(2,3-DiMethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidineMethanol Hydrochloride
• (R)-(+)-a-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol
• (R)-(+)-(-(2,3-Dimethoxyphenyl)-1-[2-(4-fluoro-phenyl)ethyl]-4-piperidine methanol (R,R)-tartrate

4-Piperidinemethanol, α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-, (αR)-

CAS: 139290-65-6

Formula: C₂₂H₂₈FNO₃

Purity: 99%

Color and Shape: Solid

Molecular weight: 373.4610

Ref: IN-DA001AP3

Volinanserin

CAS: 139290-65-6

Volinanserin

Purity: ≥98%

Molecular weight: 373.46g/mol

Ref: 54-BUP13230

Volinanserin

CAS: 139290-65-6

Volinanserin (MDL100907) is a potent 5-HT2 receptor antagonist with a Ki of 0.36 nM, 300x selective over 5-HT1c, alpha-1, and sigma receptors.

Formula: C₂₂H₂₈FNO₃

Purity: 98.94% - 99.95%

Color and Shape: Solid

Molecular weight: 373.46

Ref: TM-T5389

Volinanserin HCl

CAS: 139290-65-6

Formula: C₂₂H₂₈FNO₃·HCl

Molecular weight: 373.47 36.46

Ref: 4Z-V-100001

(R)-(2,3-Dimethoxyphenyl)(1-(4-fluorophenethyl)piperidin-4-yl)methanol

CAS: 139290-65-6

Purity: 95.0%

Molecular weight: 373.4679870605469

Ref: 10-F436152

Volinanserin Hydrochloride Salt

CAS: 139290-65-6

Applications A serotonin 5-HT2A receptor antagonist. Used as potential controls in various biological studies.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wong, D.F., et al.: Science, 226, 1393 (1984), Blin, J., et al.: Eur. J. Pharmacol., 147, 73 (1988), Kehne, J.H., et al.: J. Pharmacol. Exp. Ther., 277, 968 (1996),

Formula: C₂₂H₂₈FNO₃

Color and Shape: Neat

Molecular weight: 373.46

Ref: TR-V755000

MDL 100907

CAS: 139290-65-6

Selective antagonist of the serotonin receptors 5-HT2A with subnanomolar affinity. The compound has clozapine-like anti-psychotic properties and more favourable CNS safety profile than traditional anti-psychotics. MDL 100907 has been used in studies on antisocial behaviour in mice and shown that the blockage of 5-HT2A receptors leads to decreased post-traumatic aggression and bradycardia.

Formula: C₂₂H₂₈FNO₃

Purity: Min. 95%

Color and Shape: White Solid

Molecular weight: 373.46 g/mol

Ref: 3D-FV28720