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CAS 139314-01-5

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Quilostigmine

Description:
Quilostigmine is a chemical compound classified as a reversible inhibitor of the enzyme acetylcholinesterase, which plays a crucial role in the breakdown of the neurotransmitter acetylcholine in the synaptic cleft. This inhibition leads to an increase in acetylcholine levels, enhancing cholinergic transmission. Quilostigmine is structurally related to other anticholinesterase agents and is primarily investigated for its potential therapeutic applications in conditions such as myasthenia gravis and other disorders characterized by impaired neuromuscular transmission. The compound exhibits a moderate to high affinity for the active site of acetylcholinesterase, contributing to its efficacy. Additionally, Quilostigmine's pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are essential for determining its clinical utility and safety profile. As with other anticholinesterase agents, potential side effects may include cholinergic crisis symptoms, necessitating careful monitoring during treatment. Overall, Quilostigmine represents a significant area of research in neuropharmacology, particularly in enhancing neuromuscular function.
Formula:C23H27N3O2
InChI:InChI=1/C23H27N3O2/c1-23-11-13-24(2)21(23)25(3)20-9-8-18(14-19(20)23)28-22(27)26-12-10-16-6-4-5-7-17(16)15-26/h4-9,14,21H,10-13,15H2,1-3H3/t21-,23+/m1/s1
Synonyms:
  • Quilostigmine [USAN]
  • (3aS,8aR)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-yl 3,4-dihydro-2(1H)-isoquinolinecarboxylate
  • 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-yl ester, (3aS-cis)
  • Hp 290
  • Nxx 066
  • Unii-2L1Yno4Sqj
  • (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl 3,4-dihydroisoquinoline-2(1H)-carboxylate
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Found 3 products.
  • Quilostigmine
    Targetmol
    + Info

    Quilostigmine

    CAS:
    <p>Quilostigmine is a cholinergic.</p>
    Formula:C23H27N3O2
    Color and Shape:Solid
    Molecular weight:377.48

    Ref: TM-T34223

  • Quilostigmine
    TRC
    + Info

    Quilostigmine

    Controlled Product
    CAS:
    <p>Applications Quilostigmine is an acetylcholinesterase inhibitor used for Alzheimer's disease treatment.<br>References Snape, M., et al.: Neuropharmacology, 38, 181 (1999); Dahlin, M., Bjork, E.: Int. J. Pharm., 212, 267 (2001); Chaudhaery, S., et al.: J. Med. Chem., 53, 6490 (2010);<br></p>
    Formula:C23H27N3O2
    Color and Shape:Neat
    Molecular weight:377.479

    Ref: TR-Q550505

    100mg
    1,530.00€
  • Quilostigmine
    Biosynth
    + Info

    Quilostigmine

    CAS:
    <p>Quilostigmine is a molecule that binds to the nicotinic acetylcholine receptor and inhibits ion channels. It is used in research as a pharmacological tool for studying the function of ion channels, as well as for its potential use in the treatment of Alzheimer's disease. Quilostigmine has been shown to be an inhibitor of cholinesterase, which breaks down acetylcholine, and may have therapeutic applications in treating myasthenia gravis. Quilostigmine is currently being researched for its ability to inhibit protein interactions with ligands and receptors. This drug is also an antibody-binding reagent that can be used in cell biology and immunology experiments to identify cells or antibodies.</p>
    Formula:C23H27N3O2
    Purity:Min. 95%
    Molecular weight:377.50 g/mol

    Ref: 3D-PFA31401

    100mg
    864.00€