CAS 139340-56-0

Darbufelone mesilate

Description:

Darbufelone mesilate is a non-steroidal anti-inflammatory drug (NSAID) that has been studied for its potential therapeutic effects, particularly in the treatment of pain and inflammation. It is characterized by its ability to inhibit cyclooxygenase enzymes, which play a crucial role in the biosynthesis of prostaglandins, mediators of inflammation and pain. The substance is typically presented as a mesilate salt, enhancing its solubility and bioavailability. Darbufelone has shown promise in preclinical and clinical studies for its efficacy in managing conditions such as osteoarthritis and rheumatoid arthritis. Its pharmacological profile suggests a favorable safety margin, although, like all NSAIDs, it may carry risks of gastrointestinal and cardiovascular side effects. The compound's chemical structure includes specific functional groups that contribute to its activity and solubility. Ongoing research continues to explore its full therapeutic potential and mechanisms of action, aiming to optimize its use in clinical settings while minimizing adverse effects.

Formula: C₁₈H₂₄N₂O₂S·CH₄O₃S

InChI: InChI=1/C18H24N2O2S.CH4O3S/c1-17(2,3)11-7-10(8-12(14(11)21)18(4,5)6)9-13-15(22)20-16(19)23-13;1-5(2,3)4/h7-9,21H,1-6H3,(H2,19,20,22);1H3,(H,2,3,4)/b13-9-;

InChI key: InChIKey=BAZGFSKJAVQJJI-CHHCPSLASA-N

SMILES: C(\C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)=C\2/C(=O)N=C(N)S2.S(C)(=O)(=O)O

Synonyms:

• (5Z)-2-Amino-5-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]-1,3-thiazol-4-one methanesulfonate
• (5Z)-2-amino-5-[(3,5-di-tert-butyl-4-hydroxyphenyl)methylidene]-1,3-thiazol-4(5H)-one methanesulfonate (salt)
• 4(5H)-Thiazolone, 2-amino-5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-, (5Z)-, methanesulfonate (1:1)
• 4(5H)-Thiazolone, 2-amino-5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-, (5Z)-, monomethanesulfonate (salt)
• 4(5H)-Thiazolone, 2-amino-5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-, (Z)-, monomethanesulfonate (salt)
• Ci 1004
• Darbufelone mesylate
• DARBUFELONE MESILATE
• CI-1004 mesylate

Darbufelone mesylate

CAS: 139340-56-0

Darbufelone mesylate

Purity: ≥95%

Molecular weight: 428.57g/mol

Ref: 54-BUP21559

Darbufelone mesylate

CAS: 139340-56-0

Darbufelone mesylate blocks PGF2α, LTB4, PGHS-2 (IC50: 0.19 μM), and PGHS-1 (IC50: 20 μM).

Formula: C₁₉H₂₈N₂O₅S₂

Purity: 96.81% - 99.92%

Color and Shape: Solid

Molecular weight: 428.57

Ref: TM-T10960L

Darbufelone mesylate

CAS: 139340-56-0

Darbufelone mesylate is a non-steroidal anti-inflammatory drug that belongs to the group of fatty acid derivatives, and it has been shown to be effective against chronic bronchitis. It has also been shown to inhibit the production of leukotrienes and prostaglandins, which are mediators of inflammation. Darbufelone mesylate inhibits the synthesis of leukotrienes by blocking the action of cyclooxygenase-2 (COX-2) and adenosine receptors. This drug is also used in cancer treatment, although its effects on tumor cells are not well understood.

Formula: C₁₉H₂₈N₂O₅S₂

Purity: Min. 95%

Molecular weight: 428.6 g/mol

Ref: 3D-PFA34056