CAS 1393477-72-9

Selinexor

Description:

Selinexor is a small molecule inhibitor that primarily targets the exportin 1 (XPO1) protein, which plays a crucial role in the nuclear export of various tumor suppressor proteins. This compound is classified as an antineoplastic agent and is primarily used in the treatment of certain types of cancers, particularly multiple myeloma and diffuse large B-cell lymphoma. Selinexor is known for its ability to induce apoptosis in cancer cells by preventing the export of pro-apoptotic factors from the nucleus. The substance is typically administered orally and has a unique mechanism of action compared to traditional chemotherapy agents. Its efficacy is often evaluated in combination with other therapies to enhance treatment outcomes. Selinexor's side effects may include fatigue, nausea, and cytopenias, which are common in cancer treatments. As a targeted therapy, it represents a significant advancement in the approach to cancer treatment, focusing on the molecular pathways involved in tumor growth and survival.

Formula: C₁₇H₁₁F₆N₇O

InChI: InChI=1S/C17H11F6N7O/c18-16(19,20)11-5-10(6-12(7-11)17(21,22)23)15-26-9-30(29-15)4-1-14(31)28-27-13-8-24-2-3-25-13/h1-9H,(H,25,27)(H,28,31)/b4-1-

InChI key: InChIKey=DEVSOMFAQLZNKR-RJRFIUFISA-N

SMILES: C(F)(F)(F)C=1C=C(C=C(C(F)(F)F)C1)C2=NN(/C=C\C(NNC=3C=NC=CN3)=O)C=N2

Synonyms:

• (Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide
• (Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyrazin-2-ylprop-2-enehydrazide
• 2-Propenoic acid,3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-,2-(2-pyrazinyl)hydrazide,(2Z)
• Kpt-330
• Selinexor (KPT-330)
• Unii-31Tz62Fo8F
• Xpovio
• Selinexor

2-Propenoic acid, 3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 2-(2-pyrazinyl)hydrazide, (2Z)-

CAS: 1393477-72-9

Formula: C₁₇H₁₁F₆N₇O

Purity: 98%

Color and Shape: Solid

Molecular weight: 443.3060

Ref: IN-DA001ASN

Selinexor (KPT-330)

CAS: 1393477-72-9

Selinexor (KPT-330)

Purity: ≥98%

Molecular weight: 443.31g/mol

Ref: 54-BUP02261

Selinexor

CAS: 1393477-72-9

Formula: C₁₇H₁₁F₆N₇O

Molecular weight: 443.31

Ref: 4Z-K-031031

Selinexor (KPT-330)

CAS: 1393477-72-9

Selinexor (KPT-330) is an orally available, small molecule inhibitor of CRM1 (exportin 1 or XPO1), with potential antineoplastic activity.

Formula: C₁₇H₁₁F₆N₇O

Purity: 98% - 99.97%

Color and Shape: Solid

Molecular weight: 443.31

Ref: TM-T6106