CAS 1394-48-5

Guan-fu base A

Description:

Guan-fu base A, with the CAS number 1394-48-5, is a naturally occurring alkaloid derived from the plant species *Guanfucao* (also known as *Guan-fu*). This compound is characterized by its complex molecular structure, which includes multiple functional groups that contribute to its biological activity. Guan-fu base A has been studied for its potential pharmacological properties, including anti-inflammatory and analgesic effects. It exhibits a moderate level of solubility in organic solvents, while its solubility in water is limited. The compound's stability can be influenced by environmental factors such as pH and temperature. In terms of safety, like many alkaloids, Guan-fu base A may have toxicological implications, necessitating careful handling and usage in research and therapeutic contexts. Its unique properties make it a subject of interest in medicinal chemistry and natural product research, where it may serve as a lead compound for the development of new therapeutic agents.

Formula: C₂₄H₃₁NO₆

InChI: InChI=1/C24H31NO6/c1-10-5-22-8-14-17-21(4)6-13(30-11(2)26)7-23(17)18(22)16(28)15(10)19(31-12(3)27)24(22,29)20(23)25(14)9-21/h13-20,28-29H,1,5-9H2,2-4H3/t13-,14?,15+,16+,17+,18?,19?,20?,21-,22?,23?,24-/m0/s1

InChI key: InChIKey=OGNUSOJAYIHLNS-UVXYKNMHSA-N

SMILES: O[C@@]12[C@@]3([C@]45[C@]6([C@]1(C[C@]7([C@@]4([C@](C)(CN37)C[C@H](OC(C)=O)C5)[H])[H])CC(=C)[C@]([C@H]6O)([C@H]2OC(C)=O)[H])[H])[H]

Synonyms:

• (2Alpha,9Xi,11Alpha,20Xi)-11,14-Dihydroxyhetisan-2,13-Diyl Diacetate
• 1H,4H,7H-6a,9-Ethano-5,7,10b-methenodibenz[cd,f]indole, hetisan-2,11,13,14-tetrol deriv.
• Acehytisine
• Brn 5165899
• Hetisan-2,11,13,14-tetrol, 2,11-diacetate, (2-alpha,11-alpha,13R)-
• Hetisan-2,11,13,14-tetrol, 2,13-diacetate, (2α,11α,13R)-
• Kwan-Fu Base A
• Guan-fu base A
• (2alpha,11alpha,13R)-Hetisan-2,11,13,14-tetrol 2,13-diacetate
• Guan-fu base A USP/EP/BP
• (2α,11α,13R)-Hetisan-2,11,13,14-tetrol 2,11-diacetate

(2S,3aR,3a1R,5aS,6aR,7R,8R,9R,10S,10aS,10bS,11S)-7,10-Dihydroxy-3a-methyl-12-methylenedecahydro-1H,4H,7H-5,7,10b-(epimethanetriyl)-6a,9-ethanodibenzo[cd,f]indole-2,8-diyl diacetate

CAS: 1394-48-5

Formula: C₂₄H₃₁NO₆

Purity: 98%

Molecular weight: 429.5060

Ref: IN-DA001AY4

Guanfu base A

CAS: 1394-48-5

Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.

Formula: C₂₄H₃₁NO₆

Purity: 99.71% - 99.85%

Color and Shape: Solid

Molecular weight: 429.5

Ref: TM-T8182

Guanfu base A

CAS: 1394-48-5

Guanfu base A

Purity: ≥98%

Molecular weight: 429.5g/mol

Ref: 54-BUP01528

Acehytisine

CAS: 1394-48-5

Formula: C₂₄H₃₁NO₆

Purity: 95%~99%

Molecular weight: 429.513

Ref: BP-BP4602

Guan-fu A

CAS: 1394-48-5

Guan-fu A is a calcium channel blocker, which is derived from natural plant sources. It functions by inhibiting the influx of calcium ions across cellular membranes, specifically targeting the L-type calcium channels. This modulation of calcium ion flow impacts cardiac and smooth muscle contraction, making it highly relevant for cardiovascular research.

Formula: C₂₄H₃₁NO₆

Purity: Min. 95%

Molecular weight: 429.5 g/mol

Ref: 3D-BAA39448