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CAS 139404-48-1

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Tiotropium bromide hydrate

Description:
Tiotropium bromide hydrate is a long-acting anticholinergic medication primarily used in the management of chronic obstructive pulmonary disease (COPD) and asthma. It functions by inhibiting the action of acetylcholine on muscarinic receptors in the airways, leading to bronchodilation and improved airflow. The substance is typically administered via inhalation, allowing for localized effects in the lungs while minimizing systemic exposure. Tiotropium bromide is characterized by its high affinity for M3 muscarinic receptors, which are predominantly found in bronchial smooth muscle. The hydrate form indicates the presence of water molecules in its crystalline structure, which can influence its solubility and stability. In terms of physical properties, tiotropium bromide is a white to off-white powder, and it is soluble in water and various organic solvents. Its pharmacokinetics include a prolonged duration of action, allowing for once-daily dosing, which enhances patient compliance. Overall, tiotropium bromide hydrate is a critical therapeutic agent in respiratory medicine, providing significant benefits in managing obstructive airway diseases.
Formula:C19H22BrNO4S2·H2O
Synonyms:
  • (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide hydrate (1:1:1)
  • 7-{[Hydroxy(Dithiophen-2-Yl)Acetyl]Oxy}-9,9-Dimethyl-3-Oxa-9-Azoniatricyclo[3.3.1.02,4]Nonane Bromide Hydrate (1:1:1)
  • Tiotropium Bromide Monohydrate
  • Tiotropium
  • (1a,2b,4b,5a,7b)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide
  • (1a,2b,4b,5a,7b)-7-[(hydroxydi-2-thienylacety l)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide hydrate
  • TIOTROPIUM BROMIDE
  • (1R,2R,4S,5S,7S)-7-[2-HYDROXY-2,2-DI(2-THIENYL)ACETOXY]-9,9-DIMETHYL-3-OXA-9-AZONIATRICYCLO[3.3.1.02,4] NONANE BROMIDE MONOHYDRATE
  • tiotropium bromide hydrate
  • TIOTROPIUM BROMDIE
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