CAS 139481-72-4

Trityl Candesartan

Description:

Trityl Candesartan, with the CAS number 139481-72-4, is a chemical compound that belongs to the class of angiotensin II receptor antagonists, specifically designed for the treatment of hypertension and heart failure. It is a prodrug of Candesartan, which means it is converted into its active form in the body. The structure of Trityl Candesartan features a trityl group, which enhances its lipophilicity and bioavailability. This compound exhibits high affinity for the angiotensin II receptor, leading to vasodilation and a subsequent reduction in blood pressure. Its pharmacokinetic profile includes good absorption and a relatively long half-life, allowing for once-daily dosing. Additionally, Trityl Candesartan is characterized by its stability under physiological conditions, making it suitable for therapeutic applications. As with many pharmaceuticals, it is essential to consider potential side effects and contraindications, which may include dizziness, hypotension, and renal impairment. Overall, Trityl Candesartan represents a significant advancement in antihypertensive therapy.

Formula: C₄₃H₃₄N₆O₃

InChI: InChI=1/C43H34N6O3/c1-2-52-42-44-38-24-14-23-37(41(50)51)39(38)48(42)29-30-25-27-31(28-26-30)35-21-12-13-22-36(35)40-45-46-47-49(40)43(32-15-6-3-7-16-32,33-17-8-4-9-18-33)34-19-10-5-11-20-34/h3-28H,2,29H2,1H3,(H,50,51)

InChI key: InChIKey=VBMKOTRJWPIKMG-UHFFFAOYSA-N

SMILES: C(N1C(=NN=N1)C2=C(C=CC=C2)C3=CC=C(CN4C=5C(N=C4OCC)=CC=CC5C(O)=O)C=C3)(C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8

Synonyms:

• 1H-benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-
• 2-Ethoxy-1-((2′-(1-trityl-1H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid
• 2-Ethoxy-1-[(2′-(1-trityl-1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl)methyl]-7-benzimidazolecarboxylic acid
• 2-Ethoxy-1-[[2′-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1′-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid
• 2-Ethoxy-1-{[2'-(1-trityl-1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-benzimidazole-7-carboxylic acid
• 2-Ethoxy-1-{[2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid
• 2-ethoxy-1-[[(2'-(1-triphenylmethyl-1h-tetrazol-5-yl)biphenyl-4-yl)methyl]benzimidazole-7-carboxylic acid
• DISCONTINUED
• TritylCandesartan[CandesartabCilexetilIntermediates]
• Candesartan Cilexetil Impurity 9
• 2-Ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-c
• 2-ETHOXY-1-[[(2-(1-TRIPHENYLMETHYL-1H-TETRAZOL-5-YL)BIPHENYL)METHYL] BENZIMIDAZOLE-7-CARBOXYLIC ACID
• 2-ethoxy-3-[[4-[2-[1-(triphenylmethyl)-5-tetrazolyl]phenyl]phenyl]methyl]-4-benzimidazolecarboxylic acid
• (Trityl candesartan)2-Ethoxy-1-[[2-(2-Triphenyl Methyl)-2H-Tetrazole-5-YL](1,1-Biphenyl)-4-YL]Methyl]Benzimidazole-2-Carboxylic Acid
• Triphenyl Candesartan
• Candesartan N1-Trityl IMpurity
• (1H)-Benzimidazole-7-carboxylicacid
• 2-Ethoxy-1-[[(2’-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-yl-)methyl]benzimidazole-7-carboxylicacid
• Trityl candesartan/2-Ethoxy-1-[[(2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-yl)methyl]benzimidazole-7-carboxylic acid
• Candesartan Impurity 8
• TRITYL CANDESARTAN
• TRITYL CANDESARTAN ( FOR CANDESARTAN CILEXETIL )
• Trityl candesartan USP/EP/BP
• Yl][1,1?-Biphenyl]-4-Yl]Methyl]-1H-Benzimidazole-7- Carboxylic Acid [N-Trityl Candesartan]
• N-Trityl Candesartan
• 2-Ethoxy-1-[[2?-[2-(Triphenylmethyl)-2H-Tetrazol-5-
• 2-ethoxy-1-[[(2-(1-triphenylmethyl-1Htetrazol-5-yl)biphenyl-4-yl-)
• CANDESARTAN INTERMEDIATE A
• Intermediate 5
• 2-Ethoxy-1-[[2-(2-Triphenylmethyl)-2H-Tetrazole-5-Yl](1,1-Biphenyl)-4-Yl]-Methyl]Benzimidazole-7-Carboylicacid
• Candesartan Cilexetil
• N-trimethylcandesartan
• Candesartan Cilexetil Impurity 14
• Trityl Candesartan (C9)
• 2-Ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-
• TritylCandesartan,CandesartanCilexetil

Trityl candesartan

CAS: 139481-72-4

Formula: C₄₃H₃₄N₆O₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 682.7685

Ref: IN-DA007Z8Q

2-Ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid

CAS: 139481-72-4

2-Ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid

Purity: 97%

Molecular weight: 682.78g/mol

Ref: 54-OR1068771

N-Trityl Candesartan

CAS: 139481-72-4

Formula: C₄₃H₃₄N₆O₃

Color and Shape: White To Off-White Solid

Molecular weight: 682.79

Ref: 4Z-C-0113

Trityl candesartan

CAS: 139481-72-4

Trityl candesartan is a crucial intermediate used in the synthesis of Candesartan and Candesartan cilexetil, which are angiotensin II receptor antagonists.

Formula: C₄₃H₃₄N₆O₃

Purity: 98.97%

Color and Shape: Solid

Molecular weight: 682.77

Ref: TM-T65740

N-Trityl Candesartan

CAS: 139481-72-4

Formula: C₄₃H₃₄N₆O₃

Molecular weight: 682.77

Ref: ST-EA-CP-C50018

N-Trityl candesartan

CAS: 139481-72-4

N-Trityl candesartan is a benzimidazole derivative. It is a prodrug that is activated by esterases to the active form, candesartan. Candesartan has been shown to be effective in the treatment of high blood pressure when combined with cilexetil, but not when used alone. The regression analysis data showed that N-trityl candesartan was more potent than candesartan in lowering blood pressure in rats. This analog also had improved uptake and metabolism compared to its parent compound.

Formula: C₄₃H₃₄N₆O₃

Purity: Min. 95%

Molecular weight: 682.77 g/mol

Ref: 3D-FT28595