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CAS 13949-67-2

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2-(1-Naphthalenyloxy)propanoic acid

Description:
2-(1-Naphthalenyloxy)propanoic acid, also known as naproxen, is a nonsteroidal anti-inflammatory drug (NSAID) characterized by its ability to reduce inflammation, pain, and fever. It features a propanoic acid backbone with a naphthalenyl ether substituent, which contributes to its pharmacological properties. The compound exhibits moderate solubility in organic solvents and limited solubility in water, which influences its bioavailability and formulation in pharmaceutical applications. Its mechanism of action primarily involves the inhibition of cyclooxygenase enzymes (COX-1 and COX-2), leading to decreased synthesis of prostaglandins, the mediators of inflammation and pain. The substance is typically administered orally and is known for its relatively long half-life, allowing for less frequent dosing. Additionally, it has a well-established safety profile, although potential side effects may include gastrointestinal discomfort and cardiovascular risks. Overall, 2-(1-Naphthalenyloxy)propanoic acid is a significant compound in the realm of analgesics and anti-inflammatory medications.
Formula:C13H12O3
InChI:InChI=1S/C13H12O3/c1-9(13(14)15)16-12-8-4-6-10-5-2-3-7-11(10)12/h2-9H,1H3,(H,14,15)
InChI key:InChIKey=KTAVXDDWEGVLRN-UHFFFAOYSA-N
SMILES:O(C(C(O)=O)C)C=1C2=C(C=CC1)C=CC=C2
Synonyms:
  • 2-(1-Naphthoxy)Propionoic Acid
  • 2-(1-Naphthyloxy)propanoic acid
  • 2-(Naphthalen-1-Yloxy)Propanoic Acid
  • NSC 523899
  • Propanoic acid, 2-(1-naphthalenyloxy)-
  • Propionic acid, 2-(1-naphthyloxy)-
  • 2-(1-Naphthalenyloxy)propanoic acid
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