CAS 139504-50-0

Maytansinoid DM 1

Description:

Maytansinoid DM1 is a synthetic derivative of maytansine, a potent cytotoxic compound originally derived from the plant Maytenus serrata. It is characterized by its ability to inhibit microtubule polymerization, which disrupts mitotic spindle formation, leading to cell cycle arrest and apoptosis in rapidly dividing cancer cells. DM1 is often utilized in antibody-drug conjugates (ADCs) due to its high potency and specificity for tumor cells. The compound exhibits a relatively low solubility in aqueous solutions, which can pose challenges for formulation and delivery. Its mechanism of action is similar to that of other microtubule-targeting agents, making it a valuable candidate in targeted cancer therapies. Additionally, DM1 has been studied for its potential effectiveness against various types of malignancies, including breast cancer and other solid tumors. Safety and efficacy profiles are continuously evaluated in clinical settings to optimize its therapeutic use while minimizing adverse effects.

Formula: C₃₅H₄₈ClN₃O₁₀S

InChI: InChI=1S/C35H48ClN3O10S/c1-19-10-9-11-26(46-8)35(44)18-25(47-33(43)37-35)20(2)31-34(4,49-31)27(48-32(42)21(3)38(5)28(40)12-13-50)17-29(41)39(6)23-15-22(14-19)16-24(45-7)30(23)36/h9-11,15-16,20-21,25-27,31,44,50H,12-14,17-18H2,1-8H3,(H,37,43)/b11-9+,19-10+/t20-,21+,25+,26-,27+,31+,34+,35+/m1/s1

InChI key: InChIKey=ANZJBCHSOXCCRQ-FKUXLPTCSA-N

SMILES: C[C@]12[C@@](O1)([C@H](C)[C@@]3(C[C@](O)([C@H](OC)/C=C/C=C(\C)/CC4=CC(N(C)C(=O)C[C@@H]2OC([C@@H](N(C(CCS)=O)C)C)=O)=C(Cl)C(OC)=C4)NC(=O)O3)[H])[H]

Synonyms:

• Mertansine
• DM 1
• N2′-Deacetyl-N2′-(3-mercapto-1-oxopropyl)maytansine
• Maytansine, N2′-deacetyl-N2′-(3-mercapto-1-oxopropyl)-
• Maytansinoid DM 1

Maytansine, N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-

CAS: 139504-50-0

Formula: C₃₅H₄₈ClN₃O₁₀S

Purity: 97%

Color and Shape: Solid

Molecular weight: 738.2877

Ref: IN-DA001B52

Mertansine (Maytansinoid DM 1)

CAS: 139504-50-0

Formula: C₃₅H₄₈ClN₃O₁₀S

Molecular weight: 738.29

Ref: 4Z-M-116023

Mertansine

CAS: 139504-50-0

Mertansine

Purity: ≥98%

Molecular weight: 738.29g/mol

Ref: 54-BUP14362

Mertansine

CAS: 139504-50-0

Mertansine is a tubulin inhibitor and an antibody-conjugable maytansinoid alkaloid. The IC50 of Mertansine against HCT-15 and A431 cells is 0.750 and 0.04nM.Cost-effective and quality-assured.

Formula: C₃₅H₄₈ClN₃O₁₀S

Purity: 98% - >99.99%

Color and Shape: Solid

Molecular weight: 738.29

Ref: TM-T1992

Mertansine-13CD3

Controlled Product

CAS: 139504-50-0

Stability Hygroscopic
Applications Mertansine-13CD3 is the isotope labelled analog of Mertansine (M257800); a cytotoxic agent used as the cytotoxic component in antibody-drug conjugates.
References Erickson, H., et al.: Cancer Res., 66, 4426 (2006); Kellogg, B., et al.: Bioconjugate Chem., 22, 717 (2011)

Formula: C₃₄₁₃CH₄₅D₃ClN₃O₁₀S

Color and Shape: White To Off-White

Molecular weight: 742.3

Ref: TR-M257802

Mertansine

CAS: 139504-50-0

Applications Mertansine is a cytotoxic agent. It is used as the cytotoxic component in antibody-drug conjugates.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Erickson, H., et al.: Cancer Res., 66, 4426 (2006); Kellogg, B., et al.: Bioconjugate Chem., 22, 717 (2011)

Formula: C₃₅H₄₈ClN₃O₁₀S

Color and Shape: Neat

Molecular weight: 738.29

Ref: TR-M257800

Mertansine

CAS: 139504-50-0

N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine is a thiol-containing derivative of maytansine. Maytansine and its derivatives kill cells by interfering with the formation of microtubules, and causing the depolymerisation of already formed microtubules. Antibody conjugates of N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine and the murine monoclonal antibody TA. 1, using linkers containing either a disulfide bond or a thioether bond, have been synthesised. These antibody conjugates bind to the HER-2/new oncogene protein that is expressed on human breast tumor cells.

Formula: C₃₅H₄₈ClN₃O₁₀S

Purity: Min. 95%

Color and Shape: White Off-White Yellow Powder

Molecular weight: 738.29 g/mol

Ref: 3D-FD33453

Mertansine-d9

Controlled Product

CAS: 139504-50-0

Formula: C₃₅H₃₉D₉ClN₃O₁₀S

Color and Shape: Neat

Molecular weight: 747.34

Ref: TR-M257803