CAS 139504-50-0: Maytansinoid DM 1

Description: Maytansinoid DM1 is a synthetic derivative of maytansine, a potent cytotoxic compound originally derived from the plant Maytenus serrata. It is characterized by its ability to inhibit microtubule polymerization, which disrupts mitotic spindle formation, leading to cell cycle arrest and apoptosis in rapidly dividing cancer cells. DM1 is often utilized in antibody-drug conjugates (ADCs) due to its high potency and specificity for tumor cells. The compound exhibits a relatively low solubility in aqueous solutions, which can pose challenges for formulation and delivery. Its mechanism of action is similar to that of other microtubule-targeting agents, making it a valuable candidate in targeted cancer therapies. Additionally, DM1 has been studied for its potential effectiveness against various types of malignancies, including breast cancer and other solid tumors. Safety and efficacy profiles are continuously evaluated in clinical settings to optimize its therapeutic use while minimizing adverse effects.

Formula: C₃₅H₄₈ClN₃O₁₀S

InChI: InChI=1S/C35H48ClN3O10S/c1-19-10-9-11-26(46-8)35(44)18-25(47-33(43)37-35)20(2)31-34(4,49-31)27(48-32(42)21(3)38(5)28(40)12-13-50)17-29(41)39(6)23-15-22(14-19)16-24(45-7)30(23)36/h9-11,15-16,20-21,25-27,31,44,50H,12-14,17-18H2,1-8H3,(H,37,43)/b11-9+,19-10+/t20-,21+,25+,26-,27+,31+,34+,35+/m1/s1

InChI key: InChIKey=ANZJBCHSOXCCRQ-FKUXLPTCSA-N

SMILES: O=C1OC2CC(O)(N1)C(OC)C=CC=C(C)CC3=CC(OC)=C(Cl)C(=C3)N(C(=O)CC(OC(=O)C(N(C(=O)CCS)C)C)C4(OC4C2C)C)C

Synonyms:

• Mertansine
• DM 1
• N2′-Deacetyl-N2′-(3-mercapto-1-oxopropyl)maytansine
• Maytansine, N2′-deacetyl-N2′-(3-mercapto-1-oxopropyl)-
• Maytansinoid DM 1

Maytansine, N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-

CAS: 139504-50-0

• Formula: C₃₅H₄₈ClN₃O₁₀S
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 738.2877

Mertansine (Maytansinoid DM 1)

CAS: 139504-50-0

• Formula: C₃₅H₄₈ClN₃O₁₀S
• Molecular weight: 738.29

Mertansine

CAS: 139504-50-0

Mertansine is a tubulin inhibitor and an antibody-conjugable maytansinoid alkaloid. The IC50 of Mertansine against …

• Formula: C₃₅H₄₈ClN₃O₁₀S
• Purity: 100% - 99.76%
• Color and Shape: Solid
• Molecular weight: 738.29

Mertansine-13CD3

CAS: 139504-50-0

Stability Hygroscopic Applications Mertansine-13CD3 is the isotope labelled analog of Mertansine (M257800); a cytotoxic agent …

• Formula: C₃₄₁₃CH₄₅D₃ClN₃O₁₀S
• Color and Shape: White To Off-White
• Molecular weight: 742.3

Mertansine

CAS: 139504-50-0

Applications Mertansine is a cytotoxic agent. It is used as the cytotoxic component in antibody-drug …

• Formula: C₃₅H₄₈ClN₃O₁₀S
• Color and Shape: Neat
• Molecular weight: 738.29

Mertansine

CAS: 139504-50-0

N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine is a thiol-containing derivative of maytansine. Maytansine and its derivatives kill cells by interfering …

• Formula: C₃₅H₄₈ClN₃O₁₀S
• Purity: Min. 95%
• Color and Shape: White Off-White Yellow Powder
• Molecular weight: 738.29 g/mol

Mertansine-d9

CAS: 139504-50-0

• Formula: C₃₅H₃₉D₉ClN₃O₁₀S
• Color and Shape: Neat
• Molecular weight: 747.34