CAS 139551-74-9

FMOC-T-BUTYL-L-ALANINE

Description:

FMOC-T-butyl-L-alanine is a protected amino acid commonly used in peptide synthesis. It features a 9-fluorenylmethoxycarbonyl (FMOC) group, which serves as a protective group for the amino functionality, allowing for selective reactions during peptide assembly. The T-butyl group provides steric hindrance, enhancing the stability of the molecule and facilitating the purification process. This compound is typically white to off-white in appearance and is soluble in organic solvents such as dichloromethane and dimethylformamide, but is less soluble in water. Its structure includes a chiral center, making it an L-amino acid, which is important for maintaining the biological activity of peptides. FMOC-T-butyl-L-alanine is valued in solid-phase peptide synthesis due to its ease of deprotection under mild conditions, allowing for the efficient assembly of peptides while minimizing side reactions. Overall, it is a crucial building block in the field of medicinal chemistry and biochemistry for the development of peptide-based therapeutics.

Formula: C₂₂H₂₅NO₄

Synonyms:

• N-Alpha-(9-Fluoroenylmethoxycarbonyl)-Beta-T-Butyl-L-Alanine
• N-Alpha-(9-Fluoroenylmethoxycarbonyl)-Gamma-Methyl-L-Leucine
• N-(9-Fluorenylmethyloxycarbonyl)-Neopentylglycine
• N-Alpha-(9-Fluorenylmethoxycarbonyl)-Beta-T-Butyl-L-Alanine
• N-Alpha-(9-Fluorenylmethyloxycarbonyl)-L-Neopentylglycine
• N-Alpha-(9-Fluorenylmethoxycarbonyl)-Gamma-Methyl-L-Leucine
• Fmoc-(Neopentyl)Gly-Oh

L-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-methyl-

CAS: 139551-74-9

Formula: C₂₂H₂₅NO₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 367.4382

Ref: IN-DA001B9R

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4,4-dimethylpentanoic acid

CAS: 139551-74-9

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4,4-dimethylpentanoic acid

Purity: 95%

Molecular weight: 367.45g/mol

Ref: 54-OR73042

Fmoc-neopentylglycine

CAS: 139551-74-9

Fmoc-neopentylglycine is a versatile building block that can be used in the synthesis of complex compounds. It is a high quality and useful intermediate for synthesis, as well as a reaction component or scaffold. Fmoc-neopentylglycine has been shown to be an effective reagent in organic synthesis. This compound has also been used to synthesize drug candidates, including anti-cancer agents, inhibitors of protein translation, and antibiotics. Its versatility makes it a very useful building block for research chemicals and speciality chemicals.

Formula: C₂₂H₂₅NO₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 367.44 g/mol

Ref: 3D-FF49789

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4,4-dimethylpentanoic acid

CAS: 139551-74-9

Formula: C₂₂H₂₅NO₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 367.445

Ref: 10-F217817

Fmoc-t-butyl-L-alanine

CAS: 139551-74-9

Applications Fmoc-t-butyl-L-alanine is used in the synthesis arylaminoethyl amides as noncovalent inhibitors of cathepsin S. It is also an intermediate used to prepare oxamyl dipeptide caspase inhibitors developed for the treatment of stroke.
References Liu, H., et al.: Bioorg. Med. Chem. Lett., 15, 4979 (2005); Linton, S., et al.: Bioorg. Med. Chem. Lett., 14, 2685 (2004)

Formula: C₂₂H₂₅NO₄

Color and Shape: Neat

Molecular weight: 367.44

Ref: TR-F621070