CAS 13957-31-8

4-Thiouridine

Description:

4-Thiouridine is a modified nucleoside that plays a significant role in RNA biology. It is characterized by the presence of a sulfur atom at the 4-position of the uridine base, which distinguishes it from standard uridine. This modification can influence the stability and functionality of RNA molecules, affecting processes such as translation and RNA folding. 4-Thiouridine is known to participate in various biochemical pathways and is often studied for its potential applications in molecular biology and therapeutic contexts. The compound is soluble in water and exhibits properties typical of nucleosides, including the ability to form hydrogen bonds and participate in base pairing. Its unique structure allows it to interact with specific enzymes and proteins, making it a valuable tool in research focused on RNA dynamics and function. Additionally, 4-thiouridine can be incorporated into RNA during transcription, which may alter the properties of the resulting RNA strand, providing insights into the roles of modified nucleotides in cellular processes.

Formula: C₉H₁₂N₂O₅S

InChI: InChI=1S/C9H12N2O5S/c12-3-4-6(13)7(14)8(16-4)11-2-1-5(17)10-9(11)15/h1-2,4,6-8,12-14H,3H2,(H,10,15,17)/t4-,6-,7-,8-/m1/s1

InChI key: InChIKey=ZLOIGESWDJYCTF-XVFCMESISA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)NC(=S)C=C2

Synonyms:

• 1-beta-D-ribofuranosyl-4-thioxo-3,4-dihydropyrimidin-2(1H)-one
• 1-pentofuranosyl-4-thioxo-3,4-dihydropyrimidin-2(1H)-one
• Nsc 518132
• Thiouridine
• Thiouridine (VAN)
• Uridine, 4-thio-
• 4-Thiouridine

4-Thiouridine, 98+%

CAS: 13957-31-8

4-Thiouridine is a constituent of several transfer RNA's. 4-Thiouridine is a thionucleobase used as an antisense agent. Widely used for RNA analysis including RNA-RNA cross coupling and RNA labelling. 4-Thiouridine is a photoreactive (crosslinking) uridine analogue that upon phosphorylation to 4-thi

Formula: C₉H₁₂N₂O₅S

Purity: 98+%

Color and Shape: Off-white to pale yellow, Powder

Molecular weight: 260.27

Ref: 02-J60679

Uridine, 4-thio-

CAS: 13957-31-8

Formula: C₉H₁₂N₂O₅S

Purity: 98%

Color and Shape: Solid

Molecular weight: 260.2670

Ref: IN-DA001BAE

4-Thiouridine

CAS: 13957-31-8

4-Thiouridine

Purity: ≥98%

Molecular weight: 260.27g/mol

Ref: 54-BUP13522

4-Thiouridine

CAS: 13957-31-8

Formula: C₉H₁₂N₂O₅S

Purity: ≥ 98.0%

Color and Shape: Off-white to light-yellow powder

Molecular weight: 260.27

Ref: 7W-GN6085

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-4-Thioxo-3,4-Dihydropyrimidin-2(1H)-One

CAS: 13957-31-8

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-4-Thioxo-3,4-Dihydropyrimidin-2(1H)-One

Purity: 99%

Molecular weight: 260.27g/mol

Ref: 54-OR1008881

4-Thiouridine

CAS: 13957-31-8

4-Thiouridine (4-SU) enables RNA analysis via photoactivatable crosslinking and labeling.

Formula: C₉H₁₂N₂O₅S

Purity: 98.92% - 99.79%

Color and Shape: Light Yellow Powder

Molecular weight: 260.27

Ref: TM-T35648

4-Thiouridine

CAS: 13957-31-8

Formula: C₉H₁₂N₂O₅S

Purity: >95.0%(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 260.26

Ref: 3B-T4059

4-Thiouridine

Controlled Product

CAS: 13957-31-8

Applications Nucleotide analogue, essential for cell growth in certain bacterial species. This compound is also able to chelate with certain metal ions, and in tRNA it can act as a built-in antiphotomutagenic agent that protects Escherichia coli cells against mutagenesis.
References Caldeira de Araujo, A., et al.: Embo J., 5, 175 (1986), Mishima, Y., et al.: Embo J., 14, 2679 (1995),

Formula: C₉H₁₂N₂O₅S

Color and Shape: Neat

Molecular weight: 260.27

Ref: TR-T384010

4-Thiouridine

CAS: 13957-31-8

4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analogue that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labelling. 4-SU is typically used to modify RNA oligonucleotides, or in structure studies of RNA-protein complexes. The crosslinking thiol moiety is attached directly to the nucleotide base, thus 4-SU differs from the nucleoside uridine only by a single sulfur substitution. This means it can be incorporated into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will significantly impair RNA interactions or activities.

Formula: C₉H₁₂N₂O₅S

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 260.27 g/mol

Ref: 3D-NT06186

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-thioxo-3,4-dihydropyrimidin-2(1H)-one

CAS: 13957-31-8

Formula: C₉H₁₂N₂O₅S

Purity: 98%

Color and Shape: Liquid, No data available.

Molecular weight: 260.26

Ref: 10-F544789

4-Thiouridine

CAS: 13957-31-8

Formula: C₉H₁₂N₂O₅S

Molecular weight: 260.26

Ref: ST-EA-CP-C79009