CAS 1397-94-0

Antimycin A

Description:

Antimycin A is a naturally occurring antibiotic and a potent inhibitor of the mitochondrial electron transport chain, specifically targeting complex III (cytochrome bc1 complex). It is produced by various species of the bacterium Streptomyces and is known for its ability to disrupt cellular respiration in eukaryotic organisms. Antimycin A exhibits a complex structure characterized by a polycyclic ring system and multiple functional groups, which contribute to its biological activity. This compound is primarily recognized for its role in research, particularly in studies related to mitochondrial function and apoptosis, as it induces cell death by inhibiting ATP production. Additionally, Antimycin A has been investigated for its potential applications in cancer therapy and as a tool in biochemical assays. However, its use is limited due to its toxicity and potential side effects in higher organisms. Overall, Antimycin A serves as an important compound in both microbiology and biochemistry, providing insights into cellular metabolism and the mechanisms of action of antibiotics.

Formula: Unspecified

InChI: InChI=1/C28H40N2O9/c1-6-7-8-9-11-20-25(39-22(32)14-16(2)3)18(5)38-28(36)23(17(4)37-27(20)35)30-26(34)19-12-10-13-21(24(19)33)29-15-31/h10,12-13,15-18,20,23,25,33H,6-9,11,14H2,1-5H3,(H,29,31)(H,30,34)/t17-,18+,20-,23?,25+/m1/s1

Synonyms:

• (2R,3S,6S,7R,8R)-3-({[3-(formylamino)-2-hydroxyphenyl]carbonyl}amino)-2,6-dimethyl-4,9-dioxo-8-pentyl-1,5-dioxonan-7-yl 3-methylbutanoate (non-preferred name)
• (2R,6S,7R,8R)-3-({[3-(formylamino)-2-hydroxyphenyl]carbonyl}amino)-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl 3-methylbutanoate (non-preferred name)
• Antimycins A
• Antipiricullin
• Caswell No. 052B
• Ccris 924
• EPA Pesticide Chemical Code 006314
• Fintrol
• Hsdb 6417
• Virosin
• MeSH ID: D000968

Antimycin A

CAS: 1397-94-0

Antimycin A is used to study the specific sites of reactive oxygen species production in mitochondria isolated from skeletal muscle of chronic obstructive pulmonary disease patients, and its relationship with local oxidative stress induced by exercise. This Thermo Scientific Chemicals brand product

Formula: C₂₈H₄₀N₂O₉

Color and Shape: White to pale yellow, Powder

Molecular weight: 548.63

Ref: 02-J63522

Antimycin A

CAS: 1397-94-0

Formula: C₂₈H₄₀N₂O₉

Purity: (HPLC) ≥ 97.0%

Color and Shape: White, off-white or pale yellow powder

Molecular weight: 548.63

Ref: 7W-GA7114

Antimycin A

CAS: 1397-94-0

Antimycin A

Formula: C₂₈H₄₀N₂O₉

Purity: By hplc: >98% (mixture of subunits) (Typical Value in Batch COA)

Color and Shape: off-white powder

Molecular weight: 548.63g/mol

Ref: 54-BIM0142

Antimycin A

CAS: 1397-94-0

Antimycin A is an electron transport inhibitor in mitochondria. Antimycin A has application in cancer research and treatment since it inhibits the growth of human pulmonary adenocarcinoma cells by inducing cell cycle arrest and triggering apoptosis. Antimycin A also inhibits autophagy by inhibiting mETC complex III.

Formula: C₂₈H₄₀N₂O₉

Purity: - Major Component 1 (Hplc) Reported

Color and Shape: White Powder

Molecular weight: 548.63 g/mol

Ref: 3D-FA61700