CAS 1398065-69-4

Roflumilast-d4

Description:

Roflumilast-d4 is a deuterated analog of Roflumilast, which is a selective phosphodiesterase-4 (PDE4) inhibitor primarily used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma. The deuteration (indicated by the "d4" in its name) involves the substitution of hydrogen atoms with deuterium, a heavier isotope of hydrogen, which can enhance the stability and metabolic profile of the compound. This modification can also aid in pharmacokinetic studies and drug metabolism research. Roflumilast-d4 retains the core structure and biological activity of Roflumilast, which works by reducing inflammation in the airways, thus improving respiratory function. The compound is characterized by its ability to inhibit the breakdown of cyclic adenosine monophosphate (cAMP), leading to increased levels of cAMP in immune cells and subsequent anti-inflammatory effects. As a research tool, Roflumilast-d4 is valuable for studying the pharmacodynamics and pharmacokinetics of PDE4 inhibitors in various biological systems.

Formula: C₁₇H₁₄Cl₂F₂N₂O₃

Synonyms:

• N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-[(2,2,3,3-tetradeuteriocyclopropyl)methoxy]benzamide
• [2H4]-Roflumilast

Roflumilast-d4

CAS: 1398065-69-4

Formula: C₁₇H₁₀D₄Cl₂F₂N₂O₃

Color and Shape: White To Off-White Solid

Molecular weight: 407.23

Ref: 4Z-R-3710

Roflumilast-d4 (cyclopropyl-2,2,3,3-d4)

CAS: 1398065-69-4

Purity: 98 atom % D

Color and Shape: White Solid

Molecular weight: 407.24

Ref: 3U-D7364

Roflumilast-d4

Controlled Product

CAS: 1398065-69-4

Applications Labelled selective phosphodiesterase 4(PDE4) inhibitor. Antiasthmatic; in treatment of chronic obstructive pulmonary disease.
References Hatzelmann, A., et al.: J. Pharmacol. Exp. Ther., 297, 267 (2001), Schmidt, B.M.W., et al.: J. Allergy Clin. Immunol., 108, 530 (2001), Timmer, W., et al.: J. Clin. Pharmacol., 42, 297 (2002), Rabe, K.F., et al.: Lancet, 366, 563 (2005),

Formula: C₁₇D₄H₁₀Cl₂F₂N₂O₃

Color and Shape: Neat

Molecular weight: 407.23

Ref: TR-R639702

Roflumilast-d4

CAS: 1398065-69-4

Roflumilast-d4 is a deuterium-labeled derivative of the PDE4 inhibitor roflumilast, which is commonly used as a stable isotope-labeled internal standard in pharmacokinetic and metabolic studies. This compound is synthesized through the strategic incorporation of deuterium atoms, providing enhanced stability and traceability while maintaining the pharmacological properties of its non-labeled analog.

Formula: C₁₇H₁₄Cl₂F₂N₂O₃

Purity: Min. 95%

Molecular weight: 407.2 g/mol

Ref: 3D-YFC06569