CAS 139893-43-9
:Simvastatin ammonium salt
Description:
Simvastatin ammonium salt is a derivative of simvastatin, a widely used cholesterol-lowering medication belonging to the statin class. This compound is characterized by its ability to inhibit HMG-CoA reductase, an enzyme crucial for cholesterol biosynthesis in the liver. As an ammonium salt, it typically exhibits improved solubility in aqueous environments compared to its parent compound, which can enhance its bioavailability and therapeutic efficacy. The molecular structure includes a lactone ring, which is essential for its biological activity, and the presence of an ammonium group contributes to its ionic nature. Simvastatin ammonium salt is often utilized in pharmaceutical formulations, and its stability, solubility, and pharmacokinetic properties are critical for its effectiveness in managing hyperlipidemia. Additionally, it may exhibit side effects common to statins, such as muscle pain or liver enzyme alterations, necessitating monitoring during treatment. Overall, simvastatin ammonium salt represents an important compound in cardiovascular health management.
Formula:C25H40O6·H3N
InChI:InChI=1S/C25H40O6.H3N/c1-6-25(4,5)24(30)31-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-18(26)13-19(27)14-22(28)29;/h7-8,11,15-16,18-21,23,26-27H,6,9-10,12-14H2,1-5H3,(H,28,29);1H3/t15-,16-,18+,19+,20-,21-,23-;/m0./s1
InChI key:InChIKey=FFPDWNBTEIXJJF-OKDJMAGBSA-N
SMILES:O(C(C(CC)(C)C)=O)[C@@H]1[C@]2(C(C=C[C@H](C)[C@@H]2CC[C@H](C[C@H](CC(O)=O)O)O)=C[C@H](C)C1)[H].N
Synonyms:- (3R,5R)-7-((1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-3,5-dihydroxyheptanoate ammonium salt
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-,d-dihydroxy-2,6-dimethyl-, monoammonium salt, (R,dR,1S,2S,6R,8S,8aR)-
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, ammonium salt (1:1), (βR,δR,1S,2S,6R,8S,8aR)-
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, monoammonium salt, (βR,δR,1S,2S,6R,8S,8aR)-
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, monoammonium salt, [1S-[1α(βS*,δS*),2α,6β,8β,8aα]]-
- Ammonium (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutyryloxy)-1,2,6,7,8,8a-hexahydro-2,6-dimethyl-1-naphthyl]-3,5-dihydroxyheptanoate
- Ammonium simvastatin
- Simvastatin Ammouium Salt
- Simvastatin Hydroxy Acid, Ammonium Salt
- Simvastatin acid ammonium salt
- Simvastatin carboxylic acid ammonium salt
- Simvastatin hydroxyl acid ammonium salt
- Simvastatin impurity A
- See more synonyms
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Found 13 products.
Ammonium Tenivastatin ((3R,5R)-7-{((1S,2S,6R,8S,8aR)-8-[(2,2)-Dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl}-3,5-dihydroxyheptanoic acid Ammonium Salt)
CAS:Carboxylic acids w/ alcohol function but w/o other oxygen function and their derivatives, nesoiFormula:C25H43NO6Color and Shape:Off-White PowderMolecular weight:453.30904Simvastatin Hydroxy Acid (ammonium salt)
CAS:Formula:C25H43NO6Purity:95%Color and Shape:SolidMolecular weight:453.6120Simvastatin ammonium salt
CAS:Formula:C25H41NO5Purity:≥ 95.0%Color and Shape:White to light yellow, beige or light brown powderMolecular weight:435.60Simvastatin EP Impurity A Ammonium Salt (Simvastatin Acid Ammonium Salt, Tenivastatin Ammonium Salt)
CAS:Formula:C25H39O6·NH4Color and Shape:Off-White SolidMolecular weight:435.58 18.04(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-[(2,2-Dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic Acid Ammonium Salt (Tenivastatin Ammonium Salt)
CAS:Controlled ProductFormula:C25H39O6·H4NColor and Shape:NeatMolecular weight:453.61Simvastatin Hydroxy Acid Ammonium Salt
CAS:<p>Applications A metabolite of Simvastin (S485000). A competitive inhibitor of HMG-CoA reductase.<br>References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986),<br></p>Formula:C25H43NO6Color and Shape:NeatMolecular weight:453.61Simvastatin-d6 Hydroxy Acid Ammonium Salt
CAS:Controlled Product<p>Applications A deuterated metabolite of Simvastin (S485000). A competitive inhibitor of HMG-CoA reductase.<br>References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986),<br></p>Formula:C25H37D6NO6Color and Shape:White To Light Orange ColourMolecular weight:459.65Simvastatin acid ammonium
CAS:Simvastatin acid ammonium (Tenivastatin ammonium) is an HMG-CoA reductase (HMGCR) inhibitor.Formula:C25H43NO6Purity:98.3%Color and Shape:SolidMolecular weight:453.61Simvastatin hydroxy acid ammonium salt
CAS:<p>Simvastatin is a hydrated, acylated statin that is used as a lipid-lowering drug. It inhibits HMG-CoA reductase, an enzyme that plays a central role in cholesterol biosynthesis. The reaction solution can be activated by mixing with an acyltransferase and the desired acyl group. Simvastatin has a toxicity profile that includes myopathy, rhabdomyolysis, and liver failure. Simvastatin also inhibits lipoprotein lipase and prevents the hydrolysis of triglycerides to fatty acids and glycerol. This leads to reduced levels of low-density lipoproteins (LDLs) and increased levels of high-density lipoproteins (HDLs). Simvastatin is converted into an amide form by enzymatic cleavage, which may lead to metabolic inhibition.</p>Formula:C25H43NO6Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:453.61 g/mol
![(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-[(2,2-Dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaph…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F86%2Fthumb%2FMM0158.13.jpg&w=3840&q=75)
