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CAS 140-64-7

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Pentamidine isethionate

Description:
Pentamidine isethionate is a chemical compound primarily used as an antiprotozoal medication, particularly effective against certain infections caused by protozoa, such as leishmaniasis and Pneumocystis pneumonia. It is a white to off-white crystalline powder that is soluble in water and exhibits a slightly bitter taste. The compound is a salt formed from pentamidine, a diamidine derivative, and isethionic acid, which enhances its solubility and bioavailability. Pentamidine isethionate acts by interfering with the nucleic acid metabolism of the target organisms, leading to their inhibition and eventual death. It is typically administered via injection or inhalation, depending on the type of infection being treated. While effective, it can also have side effects, including hypotension, renal toxicity, and potential for pancreatitis, necessitating careful monitoring during treatment. Due to its specific action and side effect profile, pentamidine isethionate is often reserved for cases where other treatments are ineffective or contraindicated.
Formula:C19H24N4O2·2C2H6O4S
InChI:InChI=1S/C19H24N4O2.C2H6O4S/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23;3-1-2-7(4,5)6/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23);3H,1-2H2,(H,4,5,6)
InChI key:InChIKey=NYRHYBFMOOPIRI-UHFFFAOYSA-N
SMILES:C(S(=O)(=O)O)CO.C(=N)(N)C1=CC=C(OCCCCCOC2=CC=C(C(=N)N)C=C2)C=C1
Synonyms:
  • 1,5-Bis(4-amidinophenoxy)pentane diisethionate
  • 2-Hydroxyethanesulfonic Acid - 4,4'-[Pentane-1,5-Diylbis(Oxy)]Dibenzenecarboximidamide (1:1)
  • 2512Rp
  • 4,4′-Diamidino-α,ω-diphenoxypentane diisethionate
  • 4,4′-Diamidinodiphenoxypentane di(β-hydroxyethanesulfonate)
  • Aeropent
  • Banambax
  • Benzamidine, 4,4′-(pentamethylenedioxy)di-, diisethionate
  • Benzenecarboximidamide, 4,4′-[1,5-pentanediylbis(oxy)]bis-, bis(2-hydroxyethanesulfonate)
  • Diamidine
  • See more synonyms
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Found 16 products.