CAS 1400-61-9

Nystatin

Description:

Nystatin is an antifungal medication primarily used to treat fungal infections, particularly those caused by Candida species. It is a polyene macrolide antibiotic derived from the bacterium Streptomyces noursei. Nystatin exhibits a characteristic yellowish color and is soluble in dimethyl sulfoxide (DMSO) and slightly soluble in water, which limits its systemic use due to potential toxicity. The mechanism of action involves binding to ergosterol, a key component of fungal cell membranes, leading to the formation of pores that disrupt membrane integrity and result in cell death. Nystatin is typically administered topically or orally, depending on the type and location of the infection, and is commonly used in the treatment of oral thrush and skin infections. While generally well-tolerated, it can cause local irritation or allergic reactions in some individuals. Its use is contraindicated in patients with known hypersensitivity to the drug or its components. Overall, Nystatin remains an important agent in the management of superficial fungal infections.

Formula: Unspecified

InChI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-10H,2,11-17H2,1H3,(H,19,20)

SMILES: CCC=CC=CC=CC=CCCCCCCCC(=O)O

Synonyms:

• (21E,23E,25E,27E,31E,33E)-20-[(3-amino-3,6-dideoxy-D-mannopyranosyl)oxy]-4,6,8,11,12,16,18,36-octahydroxy-35,37,38-trimethyl-2,14-dioxooxacyclooctatriaconta-21,23,25,27,31,33-hexaene-17-carboxylic acid
• 33-[(3-Amino-3,6-Dideoxyhexopyranosyl)Oxy]-3,4,7,9,11,17,37-Heptahydroxy-15,16,18-Trimethyl-13-Oxo-14,39-Dioxabicyclo[33.3.1]Nonatriaconta-19,21,25,27,29,31-Hexaene-36-Carboxylic Acid
• <span class="text-smallcaps">L</span>-Nystatin
• Biofanal
• Candio-Hermal
• Ceratocide
• Diastatin
• Flagystatin
• Fungicidin
• L-Nystatin
• Moronal (antibiotic)
• Myconystatin
• Mycostatin
• Mycostatin Pastilles
• Mykostatyna
• N-[1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]-4-phenylbutan-2-aminium chloride
• Nilstat
• Nistatin
• Nistatina
• Nyotran
• Nysfungin
• Nystacid
• Nystan
• Nystatin
• Nystatin Suspension Cell Culture Tested
• Nystatin, Streptomyces noursei, Sterile, TC Grade
• Nystatine
• Nystavescent
• Nystex
• Nystop
• O-V Statin
• Octadeca-9,11,13,15-Tetraenoic Acid

Nystatin

CAS: 1400-61-9

Nystatin, 1400-61-9, is a macrolide complex with antifungal and antibiotic properties which exhibits activity against several species of yeast. Learn more.

Formula: C₄₇H₇₅NO₁₇

Color and Shape: White to pale cream, Powder

Molecular weight: 926.11

Ref: 02-J62486

NYSTATIN CRS

CAS: 1400-61-9

NYSTATIN CRS

Formula: C₁₈H₂₈O₂

Molecular weight: 276.4137

Ref: 41-N1400000

NYSTATIN RS

CAS: 1400-61-9

NYSTATIN RS

Formula: C₁₈H₂₈O₂

Molecular weight: 276.4137

Ref: 41-ICRS0369

THIRD INTERNATIONAL STANDARD FOR NYSTATIN

CAS: 1400-61-9

THIRD INTERNATIONAL STANDARD FOR NYSTATIN

Formula: C₁₈H₂₈O₂

Molecular weight: 276.4137

Ref: 41-ISA_29384

Nystatin

CAS: 1400-61-9

Aminoglycoside antibiotics

Formula: C₄₇H₇₅NO₁₇

Color and Shape: Yellow Light Tan Powder

Molecular weight: 925.5035

Ref: 45-1477003

Nystatin

CAS: 1400-61-9

Formula: C₄₇H₇₅NO₁₇

Purity: 95%

Color and Shape: Solid

Molecular weight: 926.0949

Ref: IN-DA001BY5

Nystatin

CAS: 1400-61-9

Formula: C₄₇H₇₅NO₁₇

Color and Shape: Yellow Solid

Molecular weight: 926.11

Ref: 4Z-N-082001

Nystatin hydrate

CAS: 1400-61-9

Formula: C₄₇H₇₅NO₁₇·xH₂O

Purity: ≥ 4500U/mg (dried basis)

Color and Shape: Yellow to brown-yellow powder

Molecular weight: 926.09 (anhydrous)

Ref: 7W-GA3995

Nystatin

CAS: 1400-61-9

Nystatin

Purity: ≥60%

Molecular weight: 926.1g/mol

Ref: 54-BUP18530

Nystatin hydrate, 4400 U/mg, USP grade

CAS: 1400-61-9

Formula: C₄₇H₇₅NO₁₇·xH₂O

Purity: ≤ 4.0%

Color and Shape: Yellow to dark yellow or tan powder

Molecular weight: 926.09 (anhydrous)

Ref: 7W-GP7660

Nystatin dihydrate

CAS: 1400-61-9

Nystatin dihydrate

Formula: C₄₇H₇₅NO₁₇·2H₂O

Purity: By hplc: 91 area-% (Typical Value in Batch COA)

Color and Shape: yellow powder

Molecular weight: 962.12546g/mol

Ref: 54-BIN0138

Nystatin

Controlled Product

CAS: 1400-61-9

Formula: C₄₇H₇₅NO₁₇

Color and Shape: Neat

Molecular weight: 926.09

Ref: 04-C15661000

Nystatin

CAS: 1400-61-9

Nystatin (Fungicidin) is a topical and oral antifungal agent with activity against many species of yeast and candida albicans, which is used largely to treat

Formula: C₄₇H₇₅NO₁₇

Purity: 69.55% - 99.86%

Color and Shape: Yellow Suspension

Molecular weight: 926.1

Ref: TM-T1678

Nystatin

CAS: 1400-61-9

Applications Polyene antifungal antibiotic complex containing 3 biologically active components, A1, A2, A3. Increases the permeability of the cell membrane of sensitive fungi by binding to sterols. Cell culture tested. Growth promotant.Nystatin A1 is shown.
References Brautaset, T., et al.: Chem. Biol., 7, 395 (2000), Brautaset, T., et al.: J. Biol. Chem., 278, 14913 (2003), Bruheim, P., et al.: Antimicrob. Agents Chemother., 48, 4120 (2004), Scott, L., et al.: Drugs, 67, 269 (2007),

Formula: C₄₇H₇₅NO₁₇

Color and Shape: Neat

Molecular weight: 926.09

Ref: TR-N926000

Nystatin

CAS: 1400-61-9

Nystatin is an antifungal compound, which is produced by the bacterium *Streptomyces noursei*. It functions by binding to ergosterol, a crucial component of fungal cell membranes, creating pores that lead to increased membrane permeability. This disruption results in the leakage of essential cellular components, ultimately causing cell death.

Formula: C₄₇H₇₅NO₁₇

Purity: Min. 85 Area-%

Color and Shape: Powder

Molecular weight: 926.09 g/mol

Ref: 3D-MM31116

Nystatin (Mycostatin) Solution (10000U/ml) for cell culture, Endotoxin (BET) 10.0EU/ml

CAS: 1400-61-9

Formula: C₄₇H₇₅NO₁₇

Color and Shape: Pale yellow to yellow, Suspension

Molecular weight:  926.09

Ref: SR-17565

Nystatin (Mycostatin) for cell culture, 85%, Endotoxin (BET) 0.05EU/mg

CAS: 1400-61-9

Formula: C₄₇H₇₅NO₁₇

Purity: min. 85%

Color and Shape: Yellow to slightly brownish, Powder

Molecular weight: 926.09

Ref: SR-16828

iso-Nystatin

CAS: 1400-61-9

iso-Nystatin is an antifungal compound, which is derived from the bacterium *Streptomyces noursei*. This specific strain of actinobacteria produces polyene macrolide antifungals, and iso-Nystatin is a derivative that exhibits similar bioactivity as its parent compound, Nystatin. Its mode of action is based on binding ergosterol, a crucial component of fungal cell membranes. This binding disrupts the membrane's structural integrity, inducing pore formation, which leads to ion leakage and ultimately cell lysis and fungal cell death.

Formula: C₄₇H₇₅NO₁₇

Purity: Min. 95%

Molecular weight: 926.09 g/mol

Ref: 3D-FN177277