CAS 14008-44-7

Metopimazine

Description:

Metopimazine is a chemical compound primarily used as an antiemetic and antipsychotic medication. It belongs to the class of phenothiazines, which are known for their ability to block dopamine receptors in the brain, thereby alleviating nausea and vomiting. Metopimazine is characterized by its ability to cross the blood-brain barrier, which contributes to its central nervous system effects. The compound is typically administered in the form of tablets or injections, and its pharmacological action is attributed to its antagonistic effects on both dopamine and serotonin receptors. Metopimazine is also noted for its sedative properties, making it useful in managing anxiety and agitation in certain clinical settings. Its safety profile includes potential side effects such as drowsiness, dry mouth, and, in rare cases, extrapyramidal symptoms. As with many medications, careful consideration of dosage and patient-specific factors is essential to minimize adverse effects and maximize therapeutic benefits.

Formula: C₂₂H₂₇N₃O₃S₂

InChI: InChI=1S/C22H27N3O3S2/c1-30(27,28)17-7-8-21-19(15-17)25(18-5-2-3-6-20(18)29-21)12-4-11-24-13-9-16(10-14-24)22(23)26/h2-3,5-8,15-16H,4,9-14H2,1H3,(H2,23,26)

InChI key: InChIKey=BQDBKDMTIJBJLA-UHFFFAOYSA-N

SMILES: C(CCN1CCC(C(N)=O)CC1)N2C=3C(SC=4C2=CC=CC4)=CC=C(S(C)(=O)=O)C3

Synonyms:

• 1-[3-[2-(Methylsulfonyl)-10H-phenothiazin-10-yl]propyl]-4-piperidinecarboxamide
• 1-[3-[2-(Methylsulfonyl)phenothiazin-10-yl]propyl]-4-piperidinecarboxamide
• 1-[3-[2-(Methylsulfonyl)phenothiazin-10-yl]propyl]isonipecotamide
• 1-{3-[2-(Methylsulfonyl)-10H-phenothiazin-10-yl]propyl}piperidine-4-carboxamide
• 10-[3-(4-Carbamoylpiperidino)propyl]-2-(methanesulfonyl)phenothiazine
• 14008-44-7
• 2-Methylsulfonyl-10-[3-(4-carbamoylpiperidino)propyl]phenothiazine
• 4-Piperidinecarboxamide, 1-[3-[2-(methylsulfonyl)-10H-phenothiazin-10-yl]propyl]-
• Exp 999
• Isonipecotamide, 1-[3-[2-(methylsulfonyl)phenothiazin-10-yl]propyl]-
• Rp 9965

Metopimazine

CAS: 14008-44-7

Color and Shape: Neat

Ref: 61-FOR1010.00

4-Piperidinecarboxamide, 1-[3-[2-(methylsulfonyl)-10H-phenothiazin-10-yl]propyl]-

CAS: 14008-44-7

Formula: C₂₂H₂₇N₃O₃S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 445.5981

Ref: IN-DA001C10

Metopimazine

CAS: 14008-44-7

Formula: C₂₂H₂₇N₃O₃S₂

Color and Shape: Yellow Solid

Molecular weight: 445.60

Ref: 4Z-M-361

Metopimazine

Controlled Product

CAS: 14008-44-7

Formula: C₂₂H₂₇N₃O₃S₂

Color and Shape: Neat

Molecular weight: 445.60

Ref: 86-MM1010.00

Metopimazine

CAS: 14008-44-7

Applications Metopimazine (MPZ) is used to prevent emesis during chemotherapies. Antiemetic.
References Catz, P., et al.: Int. J. Pharm., 58, 93 (1990), Sato, K., et al.: J. Pharm. Sci., 80, 104 (1991), Herrstedt, J., et al.: Cancer Chemother. Pharmacol., 33, 53 (1996), Sigsgaard, T., et al.: J. Clin. Onc., 19, 2091 (2001),

Formula: C₂₂H₂₇N₃O₃S₂

Color and Shape: Off White Solid

Molecular weight: 445.60

Ref: TR-M338760

Metopimazine

CAS: 14008-44-7

Metopimazine is a selective and peripherally restricted dopamine D3 and D2 receptors antagonist.

Formula: C₂₂H₂₇N₃O₃S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 445.6

Ref: TM-T24460