CAS 1402-83-1

Angolamycin

Description:

Angolamycin is a naturally occurring antibiotic that belongs to the class of compounds known as anthracyclines. It is produced by the fermentation of specific strains of Streptomyces bacteria. Angolamycin exhibits potent antibacterial activity, particularly against Gram-positive bacteria, and has shown efficacy in various biological assays. The compound is characterized by its complex polycyclic structure, which includes a sugar moiety that enhances its solubility and biological activity. Angolamycin's mechanism of action primarily involves the inhibition of DNA and RNA synthesis, leading to the disruption of bacterial cell growth and replication. Additionally, it has been studied for its potential anticancer properties due to its ability to intercalate into DNA. However, like many antibiotics, the use of angolamycin is subject to considerations regarding resistance and toxicity. Research continues to explore its full therapeutic potential and the possibility of modifying its structure to improve efficacy and reduce side effects.

Formula: C₄₆H₇₇NO₁₇

InChI: InChI=1/C46H77NO17/c1-13-33-29(22-57-44-41(56-12)40(55-11)37(52)25(4)60-44)43-46(8,64-43)16-14-31(49)23(2)18-28(15-17-48)38(24(3)32(50)20-34(51)61-33)62-35-19-30(47(9)10)39(26(5)58-35)63-36-21-45(7,54)42(53)27(6)59-36/h14,16-17,23-30,32-33,35-44,50,52-54H,13,15,18-22H2,1-12H3/b16-14+

InChI key: InChIKey=KZXDKUWSAVUSKI-UHFFFAOYSA-N

SMILES: CC12C(C(COC3C(OC)C(OC)C(O)C(C)O3)C(CC)OC(=O)CC(O)C(C)C(OC4CC(N(C)C)C(OC5CC(C)(O)C(O)C(C)O5)C(C)O4)C(CC=O)CC(C)C(=O)C=C1)O2

Synonyms:

• Tylosin, 2A-deoxy-12,13-epoxy-12,13-dihydro-, (1'ξ)-
• angolamycin
• 2-[(2E)-8-[5-(4,5-dihydroxy-4,6-dimethyl-oxan-2-yl)oxy-4-dimethylamino -6-methyl-oxan-2-yl]oxy-14-ethyl-10-hydroxy-15-[(5-hydroxy-3,4-dimetho xy-6-methyl-oxan-2-yl)oxymethyl]-1,5,9-trimethyl-4,12-dioxo-13,17-diox abicyclo[14.1.0]heptadec-2-en-7-yl]acetaldehyde
• Tylosin, 2A-deoxy-12,13-epoxy-12,13-dihydro-, (1′ξ)-
• Tylosin, 2A-deoxy-12,13-epoxy-12,13-dihydro-
• (14E)-2-{[(6-deoxy-2,3-di-O-methylhexopyranosyl)oxy]methyl}-3-ethyl-7-hydroxy-8,12,16-trimethyl-5,13-dioxo-10-(2-oxoethyl)-4,17-dioxabicyclo[14.1.0]heptadec-14-en-9-yl 2,3,6-trideoxy-4-O-(2,6-dideoxy-3-C-methylhexopyranosyl)-3-(dimethylamino)hexopyranoside
• angolamycin
• Angolamycin
• 4,17-Dioxabicyclo[14.1.0]heptadecane, tylosin deriv.
• (1′ξ)-2A-Deoxy-12,13-epoxy-12,13-dihydrotylosin

Angolamycin

CAS: 1402-83-1

Angolamycin is a macrolide antibiotic (antibiotic) effective against Gram-positive bacteria.

Formula: C₄₆H₇₇NO₁₇

Color and Shape: Solid

Molecular weight: 916.1

Ref: TM-T205018