Methanone, specifically the compound with the name "Methanone, [4-(2'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylMethyl)-1-piperidinyl]-" and CAS number 1402612-56-9, is a complex organic molecule characterized by its unique structural features. It contains a methanone functional group, which is indicative of a ketone, and incorporates a triazole ring, known for its stability and biological activity. The presence of a biphenyl moiety and a piperidine ring suggests potential applications in medicinal chemistry, particularly in the development of pharmaceuticals. The methoxy group enhances solubility and may influence the compound's reactivity and interaction with biological targets. This compound's intricate structure implies potential for diverse biological activities, possibly including antimicrobial or anticancer properties, although specific biological data would be necessary to confirm such effects. Overall, the combination of these functional groups and structural elements makes it a compound of interest in both synthetic and medicinal chemistry.

KT172 is a non-selective inhibitor of diacylglycerol lipase α (DAGLα) and DAGLβ. It inhibits DAGL-mediated hydrolysis of 1-stearoyl-2-arachidonoylglycerol in HEK293T cell membranes expressing recombinant DAGLα or DAGLβ (IC
50
s = 140 and 60 nM, respectively). KT172 also inhibits α/β-hydrolase 6 (ABHD6; IC
50
= 5 nM) and weakly inhibits monoacylglycerol lipase (MAGL; IC
50
= 5,000 nM) in a panel of 47 mouse serine hydrolases. It restores nicotine-stimulated GABA release in isolated ventral tegmental area (VTA) dopamine neurons from rats chronically exposed to nicotine when used at a concentration of 1 μM. KT172 decreases production of 2-arachidonoyl glycerol and subsequently reduces arachidonic acid (Item Nos.
90010
|
90010.1
|
10006607
), prostaglandin E
2
(PGE
2
; ), and PGD
2
in thioglycolate-stimulated peritoneal macrophages when administered at a dose of 5 mg/kg in mice.

Methanone, [4-(2'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylMethyl)-1-piperidinyl]-

1402612-56-9: Methanone, specifically the compound with the name "Methanone, [4-(2'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylMethyl)-1-piperidinyl]-" and CAS number 1402612-56-9, is a complex organic molecule characterized by its unique structural features. It contains a methanone functional group, which is indicative of a ketone, and incorporates a triazole ring, known for its stability and biological activity. The presence of a biphenyl moiety and a piperidine ring suggests potential applications in medicinal chemistry, particularly in the development of pharmaceuticals. The methoxy group enhances solubility and may influence the compound's reactivity and interaction with biological targets. This compound's intricate structure implies potential for diverse biological activities, possibly including antimicrobial or anticancer properties, although specific biological data would be necessary to confirm such effects. Overall, the combination of these functional groups and structural elements makes it a compound of interest in both synthetic and medicinal chemistry.

KT172, a DAGLβ inhibitor, exhibits an IC50 value of 11 nM and has applications in metabolic and inflammatory research.

CAS 1402612-56-9

Methanone, [4-(2'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylMethyl)-1-piperidinyl]-

KT172

Ref: TM-T70756