CAS 14028-44-5: Amoxapine

Description: Amoxapine is a tricyclic antidepressant that is primarily used in the treatment of major depressive disorder. Its chemical structure features a dibenzoxazepine core, which contributes to its pharmacological properties. The substance acts by inhibiting the reuptake of neurotransmitters such as norepinephrine and serotonin, thereby enhancing mood and alleviating depressive symptoms. Amoxapine also exhibits antagonist activity at certain serotonin receptors, which may contribute to its therapeutic effects. In addition to its antidepressant properties, it has been noted for its potential to cause sedation, making it useful in treating anxiety disorders as well. The compound is typically administered orally and is metabolized in the liver, with its metabolites also possessing pharmacological activity. Common side effects may include drowsiness, dry mouth, and weight gain, among others. As with all medications, it is important for patients to be monitored for any adverse effects, especially during the initial stages of treatment.

Formula: C₁₇H₁₆ClN₃O

InChI: InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2

InChI key: InChIKey=QWGDMFLQWFTERH-UHFFFAOYSA-N

SMILES: ClC=1C=CC=2OC=3C=CC=CC3N=C(C2C1)N4CCNCC4

Synonyms:

• 2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine
• 2-Chloro-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepine
• Amoxan
• Amoxapin
• Amoxapina
• Amoxapine
• Asendin
• Asendis
• Cl 67772
• Demolox
• Moxadil
• Defanyl
• 2-chloro-11-piperazin-1-yldibenzo[b,f][1,4]oxazepine
• dibenz[b,f][1,4]oxazepine, 2-chloro-11-(1-piperazinyl)-
• Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(1-piperazinyl)-
• 2-chloro-11-pipérazin-1-yldibenzo[b,f][1,4]oxazépine
• Dibenz(b,f)(1,4)oxazepine, 2-chloro-11-(1-piperazinyl)-
• 237-867-1

Amoxapine

CAS: 14028-44-5

• Formula: C₁₇H₁₆ClN₃O
• Purity: >97.0%(GC)(T)
• Color and Shape: White to Orange to Green powder to crystal
• Molecular weight: 313.79

2-Chloro-11-(1-piperazinyl)dibenzo[b,f]-1,4-oxazepine, 98%

CAS: 14028-44-5

A tricyclic norepinephrine uptake inhibitor This Thermo Scientific Chemicals brand product was originally part of …

• Formula: C₁₇H₁₆ClN₃O
• Purity: 98%
• Molecular weight: 313.78

Amoxapine

CAS: 14028-44-5

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

• Formula: C₁₇H₁₆ClN₃O
• Color and Shape: White Off-White Powder
• Molecular weight: 313.09819

Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(1-piperazinyl)-

CAS: 14028-44-5

• Formula: C₁₇H₁₆ClN₃O
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 313.7814399999999

Amoxapine

CAS: 14028-44-5

Amoxapine (CL-67772) exerts its antidepressant effect by inhibiting the re-uptake of norepinephrine and, to a …

• Formula: C₁₇H₁₆ClN₃O
• Purity: 98.25% - 98.84%
• Color and Shape: Solid
• Molecular weight: 313.78

Amoxapine

CAS: 14028-44-5

• Formula: C₁₇H₁₆ClN₃O
• Color and Shape: Pale Yellow Solid
• Molecular weight: 313.79

Amoxapine

CAS: 14028-44-5

• Formula: C₁₇H₁₆ClN₃O
• Color and Shape: Neat
• Molecular weight: 313.78

Amoxapine

CAS: 14028-44-5

• Formula: C₁₇H₁₆ClN₃O
• Color and Shape: Neat
• Molecular weight: 313.78

Amoxapine

CAS: 14028-44-5

• Formula: C₁₇H₁₆ClN₃O
• Molecular weight: 313.78

Amoxapine

CAS: 14028-44-5

Applications Antidepressant. References Takahashi, R., et al.: J. Int. Med. Res., 7, 7 (1979), Jue, …

• Formula: C₁₇H₁₆ClN₃O
• Color and Shape: White To Light Beige
• Molecular weight: 313.78

Amoxapine

CAS: 14028-44-5

Serotonin (5-HT2) receptor antagonist; inhibits norepinephrine reuptake

• Formula: C₁₇H₁₆ClN₃O
• Purity: Min. 98 Area-%
• Color and Shape: White Powder
• Molecular weight: 313.78 g/mol

Amoxapine - Bio-X ™

CAS: 14028-44-5

Amoxapine is a dibenzoxazepine- derivative tricyclic antidepressant or TCA. It is used in the treatment …

• Formula: C₁₇H₁₆ClN₃O
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 313.78 g/mol