CAS 1402836-58-1

NLG919

Description:

NLG919, with the CAS number 1402836-58-1, is a small molecule that acts as an inhibitor of the enzyme indoleamine 2,3-dioxygenase 1 (IDO1). This enzyme plays a crucial role in the metabolism of tryptophan and is involved in immune regulation, particularly in the context of cancer and autoimmune diseases. By inhibiting IDO1, NLG919 aims to enhance the immune response against tumors, making it a subject of interest in cancer immunotherapy research. The compound has been studied for its potential to improve the efficacy of other therapeutic agents, particularly in combination therapies. NLG919 is characterized by its specific binding affinity to IDO1, which is essential for its mechanism of action. Additionally, its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are critical for determining its therapeutic potential and safety profile in clinical settings. As research continues, NLG919 may contribute to the development of novel treatment strategies in oncology and immunology.

5H-Imidazo[5,1-a]isoindole-5-ethanol, α-cyclohexyl-

CAS: 1402836-58-1

Formula: C₁₈H₂₂N₂O

Purity: 98%

Color and Shape: Solid

Molecular weight: 282.3801

Ref: IN-DA001C7V

1-Cyclohexyl-2-(5H-Imidazo[5,1-A]Isoindol-5-Yl)Ethanol

CAS: 1402836-58-1

1-Cyclohexyl-2-(5H-Imidazo[5,1-A]Isoindol-5-Yl)Ethanol

Purity: 98%

Molecular weight: 282.38g/mol

Ref: 54-OR1009445

IDO-IN-7

CAS: 1402836-58-1

IDO-IN-7

Purity: ≥98%

Molecular weight: 282.38g/mol

Ref: 54-BUP12944

IDO-IN-7

CAS: 1402836-58-1

IDO-IN-7 (NLG-919 analogue) is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor.

Formula: C₁₈H₂₂N₂O

Purity: 99.32% - 99.9%

Color and Shape: Solid

Molecular weight: 282.38

Ref: TM-T1806

1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol

CAS: 1402836-58-1

Purity: 95.0%

Color and Shape: Liquid, No data available.

Molecular weight: 282.3869934082031

Ref: 10-F466563

NLG919

Controlled Product

CAS: 1402836-58-1

Applications NLG919 is a potent indoleamine-2,3-dioxygenase (IDO) pathway inhibitor and is suitable for the treatment of immunosuppression associated with cancer.
References Mautino, M.R., et al.: Cancer Res., 73, no pp. (2013); Li, M., et al.: J. Immunother. Cancer, 2, no pp. (2014)

Formula: C₁₈H₂₂N₂O

Color and Shape: Neat

Molecular weight: 282.38

Ref: TR-N630000

NLG919-d10

Controlled Product

CAS: 1402836-58-1

Applications NLG919-d10 is the isotope labelled analog of NLG919 (N630000). NLG919 is a potent indoleamine-2,3-dioxygenase (IDO) pathway inhibitor and is suitable for the treatment of immunosuppression associated with cancer.
References Mautino, M.R., et al.: Cancer Res., 73, no pp. (2013); Li, M., et al.: J. Immunother. Cancer, 2, no pp. (2014)

Formula: C₁₈H₁₂D₁₀N₂O

Color and Shape: Neat

Molecular weight: 292.44

Ref: TR-N630002