CAS 1403254-99-8

EPZ-6438

Description:

EPZ-6438, also known by its chemical name, is a small molecule inhibitor that primarily targets the enzyme EZH2 (enhancer of zeste homolog 2), which is a key component of the polycomb repressive complex 2 (PRC2). This compound is notable for its potential therapeutic applications in oncology, particularly in the treatment of certain types of cancers characterized by mutations in the EZH2 gene. EPZ-6438 exhibits selective inhibition of EZH2, leading to the reactivation of tumor suppressor genes that are silenced by the methylation of histone H3 at lysine 27 (H3K27me3). The compound has been studied in preclinical and clinical settings, demonstrating efficacy in models of lymphoma and other malignancies. Its pharmacological profile includes favorable bioavailability and a manageable safety profile, making it a candidate for further development in targeted cancer therapies. As with any investigational drug, ongoing research is essential to fully elucidate its mechanism of action, therapeutic potential, and any associated side effects.

Formula: C₃₄H₄₄N₄O₄

InChI: InChI=1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9,18-20,29H,5,10-17,21-22H2,1-4H3,(H,35,39)(H,36,40)

InChI key: InChIKey=NSQSAUGJQHDYNO-UHFFFAOYSA-N

SMILES: N(CC)(C1=C(C)C(C(NCC2=C(C)C=C(C)NC2=O)=O)=CC(=C1)C3=CC=C(CN4CCOCC4)C=C3)C5CCOCC5

Synonyms:

• E 7438
• N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4-methyl-4′-(4-morpholinylmethyl)[1,1′-biphenyl]-3-carboxamide
• Tazemetostat
• EPZ 6438
• [1,1′-Biphenyl]-3-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4-methyl-4′-(4-morpholinylmethyl)-
• Henagliflozin Proline
• E7438, Tazemetostat
• [1,1'-Biphenyl]-3-carboxamide
• N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)biphenyl-3-carboxamide
• EPZ-7438
• N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide
• CS-971
• Tazemetostat (EPZ-6438) USP/EP/BP
• EPZ-6438(E7438)
• EPZ6438; EPZ 6438; E-7438
• EPZ6438(Tazemetostat)
• N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4-methyl-4'-(4-morpholinylmethyl)-[1,1'-biphenyl]-3-carboxamide EPZ6438
• CPDB1064
• EPZ6438;EPZ 6438;E-7438;TAZEMETOSTAT
• E7438,EPZ6438, EPZ-6438

EPZ-6438

CAS: 1403254-99-8

Formula: C₃₄H₄₄N₄O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 572.7376

Ref: IN-DA009CBF

Tazemetostat-d8 (EPZ6438-d8)

CAS: 1403254-99-8

Formula: C₃₄H₃₆D₈N₄O₄

Color and Shape: White To Off-White Solid

Molecular weight: 580.80

Ref: 4Z-T-221002

Tazemetostat (EPZ6438)

CAS: 1403254-99-8

Formula: C₃₄H₄₄N₄O₄

Color and Shape: White To Off-White Solid

Molecular weight: 572.75

Ref: 4Z-T-221001

Tazemetostat

CAS: 1403254-99-8

Tazemetostat

Purity: ≥95%

Molecular weight: 572.74g/mol

Ref: 54-BUP17134

Tazemetostat (EPZ-6438)

CAS: 1403254-99-8

Tazemetostat (EPZ-6438)

Purity: 98%

Molecular weight: 572.74g/mol

Ref: 54-OR1026584

Tazemetostat

CAS: 1403254-99-8

Tazemetostat (EPZ6438): Oral EZH2 inhibitor, blocks histone H3K27 methylation, potential cancer therapy.

Formula: C₃₄H₄₄N₄O₄

Purity: 98.24% - ≥95%

Color and Shape: Solid

Molecular weight: 572.74

Ref: TM-T1788

EPZ-6438

CAS: 1403254-99-8

Ref: 7W-GW5052

EPZ 6438

Controlled Product

CAS: 1403254-99-8

Applications EPZ 6438 is a potent and selective inhibitor of EZH2.
References Knutson, S., et al.: Nat. Chem. Biol., 8, 890 (2012)

Formula: C₃₄H₄₄N₄O₄

Color and Shape: Neat

Molecular weight: 572.74

Ref: TR-E592250

TAZEMETOSTAT

CAS: 1403254-99-8

Purity: 98%

Color and Shape: Solid

Molecular weight: 572.75

Ref: 10-F794544

Tazemetostat

CAS: 1403254-99-8

Tazemetostat is an inhibitor that inhibits the activity of a number of enzymes, including transcriptional regulators, histone methyltransferases, and proteases. Tazemetostat has been shown to have significant cytotoxicity in cancer cells and potent antitumor activity against solid tumours in mice. It also has pluripotent-like effects on human embryonic stem cells and can induce differentiation of epithelial mesenchymal progenitor cells into cartilage. Tazemetostat appears to inhibit the transcriptional regulation of collagen synthesis by inhibition of the enzyme collagenase.

Formula: C₃₄H₄₄N₄O₄

Purity: Min. 95%

Color and Shape: White/Off-White Solid

Molecular weight: 572.74 g/mol

Ref: 3D-FT165032

EPZ 6438-d8

Controlled Product

CAS: 1403254-99-8

Formula: C₃₄D₈H₃₆N₄O₄

Color and Shape: Neat

Molecular weight: 580.787

Ref: TR-E592251