CAS 1403764-72-6

2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide

Description:

2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide is a chemical compound characterized by its complex structure, which includes a methoxy group, a sulfonamide moiety, and a tetrahydroquinazoline ring. This compound typically exhibits properties associated with sulfonamides, such as potential antibacterial activity, although its specific biological activity would depend on its interaction with biological targets. The presence of the methoxy group may influence its solubility and lipophilicity, while the tetrahydroquinazoline structure could contribute to its pharmacological profile. The compound is likely to be a solid at room temperature, with potential applications in medicinal chemistry, particularly in the development of new therapeutic agents. Its synthesis would involve multi-step organic reactions, and it may be characterized using techniques such as NMR spectroscopy, mass spectrometry, and infrared spectroscopy to confirm its structure and purity. As with many chemical substances, safety data sheets should be consulted for handling and toxicity information.

Formula: C₁₆H₁₇N₃O₄S

InChI: InChI=1S/C16H17N3O4S/c1-19-10-11-9-12(7-8-13(11)17-16(19)20)18-24(21,22)15-6-4-3-5-14(15)23-2/h3-9,18H,10H2,1-2H3,(H,17,20)

InChI key: InChIKey=TXZPMHLMPKIUGK-UHFFFAOYSA-N

SMILES: N(S(=O)(=O)C1=C(OC)C=CC=C1)C=2C=C3C(=CC2)NC(=O)N(C)C3

Synonyms:

• PF 6405761
• 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide
• PFI 1
• Benzenesulfonamide, 2-methoxy-N-(1,2,3,4-tetrahydro-3-methyl-2-oxo-6-quinazolinyl)-
• 2-Methoxy-N-(1,2,3,4-tetrahydro-3-methyl-2-oxo-6-quinazolinyl)benzenesulfonamide

PFI-1

CAS: 1403764-72-6

Formula: C₁₆H₁₇N₃O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 347.3889

Ref: IN-DA009CE8

2-Methoxy-N-(3-Methyl-2-Oxo-1,2,3,4-Tetrahydroquinazolin-6-yl)Benzenesulfonamide

CAS: 1403764-72-6

2-Methoxy-N-(3-Methyl-2-Oxo-1,2,3,4-Tetrahydroquinazolin-6-yl)Benzenesulfonamide

Purity: 98%

Molecular weight: 347.39g/mol

Ref: 54-OR1010527

PFI-1

CAS: 1403764-72-6

PFI-1

Purity: ≥95%

Molecular weight: 347.39g/mol

Ref: 54-BUP06229

PFI-1

CAS: 1403764-72-6

PFI-1 (PF-6405761), a specific BET (bromodomain-containing protein) inhibitor for BRD4, is with the IC50 of 0.22 μM in a cell-free assay.

Formula: C₁₆H₁₇N₃O₄S

Purity: 98.74% - 99.19%

Color and Shape: Solid

Molecular weight: 347.39

Ref: TM-T6222

PFI-1

CAS: 1403764-72-6

Purity: 95%

Molecular weight: 347.390014648438

Ref: 10-F811897

PFI-1 (PF-6405761)

CAS: 1403764-72-6

PFI-1 is a protein inhibitor that inhibits transcriptional regulation through the inhibition of histone acetylation. PFI-1 has been shown to inhibit the replication of HIV and influenza A virus in vitro. PFI-1 binds to the acetylated lysine residues on histones, preventing their acetylation by HDACs and inhibiting transcriptional regulation. The mechanism of action for PFI-1 is not well understood, but it has been shown to inhibit proliferation of prostate cancer cells and may be a potential therapeutic agent for treatment of autoimmune diseases.

Formula: C₁₆H₁₇N₃O₄S

Purity: Min. 95%

Molecular weight: 347.39 g/mol

Ref: 3D-DGC76472