CAS 1404-19-9

Oligomycin

Description:

Oligomycin is a macrolide antibiotic that is primarily known for its role as an inhibitor of ATP synthase, an essential enzyme in the process of oxidative phosphorylation in mitochondria. It is derived from the bacterium Streptomyces diastaticus and is characterized by its ability to disrupt ATP production by blocking the proton channel of ATP synthase, leading to a decrease in cellular energy production. Oligomycin is typically used in biochemical research to study mitochondrial function and energy metabolism. The substance is a white to off-white powder that is soluble in organic solvents but has limited solubility in water. Its molecular structure features a large lactone ring, which is typical of macrolide antibiotics. Due to its potent effects on cellular respiration, oligomycin is also utilized in various experimental settings to investigate the mechanisms of apoptosis and other metabolic pathways. However, it is important to handle oligomycin with care, as it can be toxic to cells at higher concentrations.

Formula: Unspecified

InChI: InChI=1/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15-,21-18+

Synonyms:

• Oligomicina
• Oligomycine
• Oligomycin

Oligomycin

CAS: 1404-19-9

Oligomycin, 1404-19-9, a mixture of oligomycin isomers A, B, and C, is a macrolide antibiotic which inhibits membrane-bound mitochondrial ATP synthase. Learn more.

Ref: 02-J61898

Oligomycin

CAS: 1404-19-9

Formula: C₄₅H₇₄O₁₁

Purity: 90%

Color and Shape: Solid

Molecular weight: 791.0625

Ref: IN-DA001CD3

Oligomycin

CAS: 1404-19-9

Oligomycin is a macrolide antibiotic produced by Streptomyces. Oligomycin has antifungal and antitumor activities. High-Quality, Low-Cost!

Purity: 98%

Color and Shape: Soild

Ref: TM-T21494

Oligomycin from Streptomyces diastatochromogenes

CAS: 1404-19-9

Oligomycin from Streptomyces diastatochromogenes

Purity: By hplc: oligomycin a: 36.08%; (Typical Value in Batch COA)

Color and Shape: white powder

Ref: 54-BIO1002

Oligomycin

CAS: 1404-19-9

Formula: C₄₅H₇₄O₁₁

Purity: ≥ 90%

Color and Shape: White to pale yellow powder

Molecular weight: 791.07

Ref: 7W-GA7095

Oligomycin

Controlled Product

CAS: 1404-19-9

Applications Oligomycin is a specific inhibitor of the mitochondrial ATP-synthase.
References Devenish, R., et al.: J. Bioenerg. Biomembr., 32, 507 (2000);

Formula: C₄₅H₇₄O₁₁

Color and Shape: Neat

Molecular weight: 791.06

Ref: TR-O532973

Oligomycin

CAS: 1404-19-9

Oligomycin is a macrolide antibiotic, which is derived from species of the bacterium Streptomyces. It acts as a potent inhibitor of the mitochondrial ATP synthase complex, specifically targeting the F₀ portion of the enzyme. This interference results in the blockage of proton translocation across the mitochondrial membrane, thereby preventing ATP synthesis. Due to this mode of action, Oligomycin is primarily utilized in biochemical research to study cellular respiration and energy metabolism. It serves as a valuable tool in elucidating the mechanisms of oxidative phosphorylation and the role of ATP in various cellular processes. In addition, its application extends to investigations on mitochondrial dysfunctions and the screening of mitochondrial-targeted drugs.

Formula: C₄₅H₇₄O₁₁

Purity: Min. 95%

Molecular weight: 791.06 g/mol

Ref: 3D-AO34961