CAS 1404-93-9

Vancomycin, hydrochloride

Description:

Vancomycin hydrochloride is a glycopeptide antibiotic primarily used to treat serious bacterial infections, particularly those caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). It is characterized by its complex structure, which includes a series of amino acids and sugar moieties that contribute to its mechanism of action. Vancomycin works by inhibiting cell wall synthesis in bacteria, ultimately leading to cell lysis and death. The hydrochloride form enhances its solubility in water, making it suitable for intravenous administration. It is typically administered in a clinical setting due to its potency and the need for monitoring potential side effects, such as nephrotoxicity and ototoxicity. Vancomycin is also notable for its spectrum of activity, which is limited to certain types of bacteria, and it is often reserved for cases where other antibiotics are ineffective. Its use is guided by susceptibility testing to ensure effectiveness and to combat the development of antibiotic resistance.

Formula: C₆₆H₇₅Cl₂N₉O₂₄·xClH

InChI: InChI=1S/C66H75Cl2N9O24.ClH/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92;/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95);1H/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-;/m0./s1

InChI key: InChIKey=LCTORFDMHNKUSG-XTTLPDOESA-N

SMILES: O(C=1C2=CC3=CC1OC=4C(Cl)=CC(=CC4)[C@@H](O)[C@@H](NC([C@@H](CC(C)C)NC)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@]3(C(=O)N[C@@]5(C=6C=C(C=7C([C@@H](C(O)=O)NC(=O)[C@]([C@H](O)C=8C=C(Cl)C(O2)=CC8)(NC5=O)[H])=CC(O)=CC7O)C(O)=CC6)[H])[H])[C@H]9[C@H](O[C@H]%10C[C@](C)(N)[C@H](O)[C@H](C)O%10)[C@@H](O)[C@H](O)[C@@H](CO)O9.Cl

Synonyms:

• (1S,2R,18R,19R,22S,25R,28R,40S)-48-{[(2S,3R,4S,5S,6R)-3-{[(2S,4S,5S,6S)-4-amino-5-hydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-{[(2R)-4-methyl-2-(methylamino)pentanoyl]amino}-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid hydrochloride (non-preferred name)
• (1S,2R,18R,19R,22S,25R,28R,40S)-48-{[(2S,3R,4S,5S,6R)-3-{[(2S,4S,5S,6S)-4-amino-5-hydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-{[(2R)-4-methyl-2-(methylamino)pentanoyl]amino}-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2~3,6~.2~14,17~.1~8,12~.1~29,33~.0~10,25~.0~34,39~]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid (non-preferred name)
• (3S-(3R*,6S*(S*),7S*,22S*,23R*,26R*,36S*,38aS*))-3-(2-Amino-2-oxoethyl)-44-((2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl)oxy)-10,19-dichloro-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-((4-methyl-2-(methylamino)-1-oxopentyl)amino)-2,5,24,38,39-pentaoxo-22H-8,11:18,21-dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H,16H-(1,6,9)oxadiazacyclohexadecino(4,5-m)(10,2,16)benzoxadiazacyclotetracosine-26-carboxylic acid, monohydrochloride
• 22H-8,11:18,21-Dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H,16H-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine, vancomycin deriv.
• 48-({3-[(4-amino-5-hydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy]-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl}oxy)-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-{[4-methyl-2-(methylamino)pentanoyl]amino}-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2~3,6~.2~14,17~.1~8,12~.1~29,33~.0~10,25~.0~34,39~]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid hydrochloride (1:1) (non-preferred name)
• Laikexin
• Lyphocin
• Unii-71Wo621Tjd
• Vancocin hydrochloride
• Vancocine hydrochloride
• Vancocyn
• Vancomycin HCl
• Vancomycin monohydrochloride
• Vancor

Vancomycin hydrochloride, Molecular Biology Grade

CAS: 1404-93-9

Vancomycin hydrochloride, 1404-93-9, is a polypeptide with antibiotic properties suitable for laboratory study of bacterial infections. Learn more at Thermo Fisher Scientific.

Formula: C₆₆H₇₆Cl₃N₉O₂₄

Color and Shape: White to tan to brown, Free-flowing powder

Molecular weight: 1485.72

Ref: 02-J62790

Vancomycin hydrochloride, 50 mg/ml in distilled water, sterile-filtered

CAS: 1404-93-9

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Ref: 02-J67251

Vancomycin Hydrochloride

CAS: 1404-93-9

Color and Shape: Neat

Ref: 61-FOR0239.00

SECOND INTERNATIONAL STANDARD FOR VANCOMYCIN

CAS: 1404-93-9

SECOND INTERNATIONAL STANDARD FOR VANCOMYCIN

Formula: C₆₆H₇₅Cl₂N₉O₂₄

Molecular weight: 1449.254

Ref: 41-ISA_39036

VANCOMYCIN FOR SYSTEM SUITABILITY CRS

CAS: 1404-93-9

VANCOMYCIN FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0002080

VANCOMYCIN HYDROCHLORIDE CRS

CAS: 1404-93-9

VANCOMYCIN HYDROCHLORIDE CRS

Formula: C₆₆H₇₅Cl₂N₉O₂₄

Color and Shape: White. Powder.

Molecular weight: 1449.254

Ref: 41-V0045000

Vancomycin B with Monodechlorovancomycin

CAS: 1404-93-9

Diagnostic or lab reagents on a backing, prepared diagnostic or lab reagents whether or not on a backing, whether or not in the form of kits, nesoi

Formula: C₆₆H₇₅Cl₂N₉O₂₄·HCl

Color and Shape: Off-White Tan Powder

Molecular weight: 1483.40688

Ref: 45-1709018

Vancomycin B

CAS: 1404-93-9

Antibiotics nesoi

Formula: C₆₆H₇₅Cl₂N₉O₂₄·HCl

Color and Shape: White Brown Powder

Molecular weight: 1485.71 g/mol

Ref: 45-1709029

Vancomycin, hydrochloride

CAS: 1404-93-9

Formula: C₆₆H₇₆Cl₃N₉O₂₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 1485.7145

Ref: IN-DA001CD1

Vancomycin hydrochloride

CAS: 1404-93-9

Vancomycin hydrochloride (Vancomycin HCl) targets peptidoglycan in bacterial cell wall synthesis. High-Quality, Low-Cost!

Formula: C₆₆H₇₆Cl₃N₉O₂₄

Purity: 97.20% - 99.19%

Color and Shape: Off White Powder

Molecular weight: 1485.71

Ref: TM-T0832

Vancomycin hydrochloride

CAS: 1404-93-9

Vancomycin hydrochloride

Formula: C₆₆H₇₅Cl₂N₉O₂₄·ClH

Purity: Heavy metals: <30 ppm. (Typical Value in Batch COA)

Color and Shape: white. almost white or tan to brown free flowing powder

Molecular weight: 1,485.71g/mol

Ref: 54-BIV0155

Vancomycin hydrochloride, low endotoxin

CAS: 1404-93-9

Formula: C₆₆H₇₅Cl₂N₉O₂₄·HCl

Purity: ≤ 5.0%

Color and Shape: White to tan powder

Molecular weight: 1485.73

Ref: 7W-GP4819

Vancomycin hydrochloride

CAS: 1404-93-9

Formula: C₆₆H₇₅Cl₂N₉O₂₄·HCl

Purity: ≤ 5.0%

Color and Shape: White to tan powder

Molecular weight: 1485.73

Ref: 7W-GA6284

Vancomycin hydrochloride BioChemica

CAS: 1404-93-9

Vancomycin hydrochloride BioChemica

Color and Shape: Solid

Molecular weight: 1,485.71g/mol

Ref: 54-BIA1839

Vancomycin hydrochloride

Controlled Product

CAS: 1404-93-9

Formula: C₆₆H₇₅Cl₂N₉O₂₄·ClH

Color and Shape: Neat

Molecular weight: 1485.71

Ref: 04-C17900500

Vancomycin Hydrochloride

Controlled Product

CAS: 1404-93-9

Formula: C₆₆H₇₅Cl₂N₉O₂₄·ClH

Color and Shape: Neat

Molecular weight: 1485.71

Ref: 86-MM0239.00

Vancomycin solution

CAS: 1404-93-9

Vancomycin solution

Color and Shape: Solution

Molecular weight: 1,485.71g/mol

Ref: 54-BIG1035

Vancomycin Hydrochloride RS

CAS: 1404-93-9

Color and Shape: White Solid Powder

Ref: 2K-7000800021

Vancomycin Hydrochloride (90%)

CAS: 1404-93-9

Stability Hygroscopic
Applications Vancomycin Hydrochloride is an antibiotic used against gram-positive bacterial strains.
References Yao, N., et al.: Biopolymers, 90, 421 (2008); Lai, H., et al.: ACS Appl. Mater. Interfaces, 7, 2046 (2015);

Formula: C₆₆H₇₅Cl₂N₉O₂₄·ClH

Purity: 90%

Color and Shape: Neat

Molecular weight: 1485.71

Ref: TR-V096533

Vancomycin HCl - pharma grade

CAS: 1404-93-9

Vancomycin is a tricyclic glycopeptide antibiotic that has bactericidal effects against staphylococci, streptococci, and other gram-positive bacteria. It is often used as an alternative treatment for severe staphylococcal and streptococcal infections, including endocarditis, and infections with MRSA (methicillin-resistant Staphylococcus aureus), penicillin-resistant pneumococci or in cases of allergy to penicillins and cephalosporins.

Formula: C₆₆H₇₅Cl₂N₉O₂₄·HCl

Color and Shape: Powder

Molecular weight: 1,485.71 g/mol

Ref: 3D-AV11352