CAS 1404559-15-4

(2S,4R)-Teneligliptin

Description:

(2S,4R)-Teneligliptin is a pharmaceutical compound primarily used as an antidiabetic agent, specifically for the management of type 2 diabetes mellitus. It belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors, which function by enhancing the levels of incretin hormones, thereby increasing insulin secretion and decreasing glucagon levels in a glucose-dependent manner. This helps to lower blood glucose levels. The compound is characterized by its specific stereochemistry, indicated by the (2S,4R) configuration, which is crucial for its biological activity. Teneligliptin exhibits good oral bioavailability and is typically administered in tablet form. Its pharmacokinetic profile includes a moderate half-life, allowing for once-daily dosing. Additionally, it has a favorable safety profile, with common side effects being mild and manageable. The compound is also noted for its potential benefits in weight management and cardiovascular health in diabetic patients. Overall, (2S,4R)-Teneligliptin represents a significant advancement in diabetes treatment options.

Formula: C₂₂H₃₀N₆OS

Synonyms:

• Teneligliptin 2S,4R
• Teneligliptin (2S,4R)-Isomer Impurity
• 3-{(2S,4R)-4-[4-(3-Methyl-1-phenyl-1H- pyrazol-5-yl)piperazin-1-yl]pyrrolidin -2-yl-carbonyl}thiazolidine
• Teneligptin API
• ((2S,4R)-4-(4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(thiazolidin-3-yl)Methanone
• Reaxys ID: 22932450
• [(2S,4R)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone
• Teneligliptin (2S,4R)-Isomer
• Methanone, [(2S,4R)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinyl-

Teneligliptin (2S,4R)-Isomer

CAS: 1404559-15-4

Formula: C₂₂H₃₀N₆OS

Molecular weight: 426.58

Ref: ST-EA-CP-T16033

Teneligliptin (2S,4R)-Isomer

CAS: 1404559-15-4

Formula: C₂₂H₃₀N₆OS

Color and Shape: Off-White Solid

Molecular weight: 426.58

Ref: 4Z-T-145005

(2S,4R)-Teneligliptin

Controlled Product

CAS: 1404559-15-4

Formula: C₂₂H₃₀N₆OS

Color and Shape: Neat

Molecular weight: 426.578

Ref: TR-T018310

(2S,4R)-Teneligliptin-d8

Controlled Product

CAS: 1404559-15-4

Formula: C₂₂H₂₂D₈N₆OS

Color and Shape: Neat

Molecular weight: 434.63

Ref: TR-T018312

(2S,4R)-Teneligliptin

CAS: 1404559-15-4

(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.

Formula: C₂₂H₃₀N₆OS

Color and Shape: Solid

Molecular weight: 426.578

Ref: TM-T206299