CAS 14047-28-0

R-(+)-9-(2-Hydroxypropyl)adenine

Description:

R-(+)-9-(2-Hydroxypropyl)adenine, with the CAS number 14047-28-0, is a purine derivative that exhibits structural similarities to adenine, a fundamental component of nucleic acids. This compound features a hydroxylpropyl group at the 2-position of the ribose moiety, which influences its biological activity and solubility. It is characterized by its potential role in biochemical processes, particularly in cellular signaling and metabolism. The presence of the hydroxypropyl group may enhance its interaction with various biological targets, making it of interest in pharmacological research. R-(+)-9-(2-Hydroxypropyl)adenine is typically studied for its effects on nucleic acid synthesis and its potential therapeutic applications. As a chiral molecule, it exists in a specific enantiomeric form, which can significantly affect its biological properties and interactions. Overall, this compound represents a valuable subject of study in medicinal chemistry and biochemistry due to its unique structural features and potential applications in drug development.

Formula: C₈H₁₁N₅O

InChI: InChI=1S/C8H11N5O/c1-5(14)2-13-4-12-6-7(9)10-3-11-8(6)13/h3-5,14H,2H2,1H3,(H2,9,10,11)/t5-/m1/s1

InChI key: InChIKey=MJZYTEBKXLVLMY-RXMQYKEDSA-N

SMILES: C([C@@H](C)O)N1C=2C(N=C1)=C(N)N=CN2

Synonyms:

• (2R)-1-(6-Aminopurin-9-yl)propan-2-ol
• (2R)-1-(6-amino-9H-purin-9-yl)propan-2-ol
• (R)-(+)-9-(2-Hydroxypropyl)adenine(PMP)
• (αR)-6-Amino-α-methyl-9H-purine-9-ethanol
• 6-Amino-alpha-methyl-9H-purine-9-ethanol
• 9-[(2R)-2-Hydroxypropyl]adenine
• 9-[2-(R)-(Hydroxy)propyl]adenine
• 9H-Purine-9-ethanol, 6-amino-α-methyl-, (R)-
• 9H-Purine-9-ethanol, 6-amino-α-methyl-, (αR)-
• 9H-Purine-9-ethanol, 6-amino-α-methyl-, <span class="text-smallcaps">D</span>-
• <span class="text-smallcaps">D</span>-(-)-9-(2-Hydroxypropyl)adenine
• D-(-)-9-(2-Hydroxypropyl)adenine
• Hydroxypropyl adenine
• (R)-(-)-9-(2-Hydroxypropyl)adenine
• (R)-9-(2-hydroxypropyl) adenine
• (R)-(+)-9-(2-hydroxypropyl)adenine
• (R)-9-(2-Hydroxypropyl)adenine

(R)-9-(2-Hydroxypropyl)adenine

CAS: 14047-28-0

Formula: C₈H₁₁N₅O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 193.21

Ref: 3B-H1291

(R)-(-)-9-(2-Hydroxypropyl)adenine

CAS: 14047-28-0

Formula: C₈H₁₁N₅O

Purity: 97%

Color and Shape: Solid

Molecular weight: 193.2058

Ref: IN-DA001CIK

Tenofovir Impurity 11

CAS: 14047-28-0

Formula: C₈H₁₁N₅O

Color and Shape: White To Off-White Solid

Molecular weight: 193.21

Ref: 4Z-T-0245

(R)-1-(6-Amino-9H-purin-9-yl)propan-2-ol

CAS: 14047-28-0

(R)-1-(6-Amino-9H-purin-9-yl)propan-2-ol

Purity: 98%

Molecular weight: 193.21g/mol

Ref: 54-OR80623

(R)-9-(2-Hydroxypropyl)adenine (Desphosphoryltenofovir)

Controlled Product

CAS: 14047-28-0

Formula: C₈H₁₁N₅O

Color and Shape: Neat

Molecular weight: 193.21

Ref: 86-MM1329.02

Tenofovir (R)-Propanol Impurity

CAS: 14047-28-0

Formula: C₈H₁₁N₅O

Molecular weight: 193.21

Ref: ST-EA-CP-T5015

(R)-9-[2-(Hydroxypropyl] Adenine(Desphosphoryl Tenofovir)

Controlled Product

CAS: 14047-28-0

Applications (R)-9-[2-(Hydroxypropyl] Adenine (Desphosphoryl Tenofovir) (cas# 14047-28-0) is a useful reagent for preparing the antiviral drug tenofovir.
References Dietz, J.-P., et al.: ChemRxiv, 1 (2020)

Formula: C₈H₁₁N₅O

Color and Shape: Neat

Molecular weight: 193.21

Ref: TR-H952560

(R)-1-(6-Amino-9H-purin-9-yl)propan-2-ol

CAS: 14047-28-0

Formula: C₈H₁₁N₅O

Purity: 95%

Molecular weight: 193.21

Ref: 10-F210203

(R)-(+)-9-(2-Hydroxypropyl)adenine

CAS: 14047-28-0

(R)-(+)-9-(2-Hydroxypropyl)adenine (HPA) is a carbocyclic nucleoside that has been shown to be effective against the human immunodeficiency virus (HIV). HPA inhibits the reverse transcriptase and integrase enzymes, which are necessary for HIV replication. It also inhibits phosphorylation of host cell proteins, leading to decreased viral protein synthesis. The reaction yield of this compound is high and it can be industrially produced with a synthetic process. HPA is synthesized from adenosine by the addition of two hydroxyl groups on the adjacent carbon atoms. HPA has a low energy ring-opening reaction with hydrogen chloride, which leads to its potent inhibition of HIV infection.

Formula: C₈H₁₁N₅O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 193.21 g/mol

Ref: 3D-FH10709