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CAS 1405-41-0

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Gentamicin sulfate

Description:
Gentamicin sulfate is an aminoglycoside antibiotic primarily used to treat various bacterial infections, particularly those caused by Gram-negative bacteria. It is derived from the bacterium Micromonospora purpurea and is known for its broad-spectrum antimicrobial activity. The substance appears as a white to pale yellow powder and is soluble in water, which facilitates its administration via injection or topical application. Gentamicin sulfate works by inhibiting bacterial protein synthesis, leading to cell death. Its pharmacokinetics involve renal excretion, necessitating careful monitoring of kidney function during treatment to avoid toxicity. Common side effects may include nephrotoxicity and ototoxicity, particularly with prolonged use or high doses. Gentamicin sulfate is often used in combination with other antibiotics to enhance efficacy against resistant strains. Due to its effectiveness and relatively low cost, it remains a critical option in the treatment of serious infections, especially in hospital settings. However, resistance can develop, necessitating judicious use and susceptibility testing when appropriate.
Formula:H2O4S·xUnspecified
InChI:InChI=1/C19H39N5O7.H2O4S/c1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h8-18,24-27H,3-7,20-23H2,1-2H3;(H2,1,2,3,4)/t8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-;/m0./s1
Synonyms:
  • 4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)pentopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2,3,4,6,7-pentadeoxy-6-(methylamino)heptopyranoside
  • Alcomicin
  • Bristagen
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  • Dispagent
  • Duragentam
  • Eltacin
  • Garamycin
  • Garasent
  • Garasol
  • See more synonyms
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