CAS 1405-89-6

Bacitracin zinc

Description:

Bacitracin zinc is an antibiotic compound that is a complex mixture of cyclic polypeptides produced by the bacterium Bacillus subtilis. It is primarily used for its antibacterial properties, particularly against Gram-positive bacteria. The zinc salt form enhances its stability and solubility, making it suitable for various applications, including topical ointments and veterinary medicine. Bacitracin zinc works by inhibiting bacterial cell wall synthesis, which ultimately leads to cell lysis and death. It is often used in combination with other antibiotics to broaden its spectrum of activity. The compound is generally considered safe for topical use, but it can cause allergic reactions in some individuals. In terms of physical properties, bacitracin zinc is typically a white to off-white powder that is soluble in water and has a slightly bitter taste. Its use is regulated, and it is important to follow guidelines to prevent the development of antibiotic resistance.

Formula: Unspecified

InChI: InChI=1/C66H103N17O16S.Zn/c1-9-35(6)52(69)66-81-48(32-100-66)63(97)76-43(26-34(4)5)59(93)74-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)75-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-72-39)77-60(94)44(27-38-18-13-12-14-19-38)80-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)73-56(40)90;/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,72)(H,71,89)(H,73,90)(H,74,93)(H,75,98)(H,76,97)(H,77,94)(H,78,96)(H,79,95)(H,80,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88);/q;+2/p-2/t35?,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48?,52?,53-,54-;/m0./s1

SMILES: CCC(C)C(C1=NC(CS1)C(=NC(CC(C)C)C(=NC(CCC(=O)O)C(=NC(C(C)CC)C(=NC1CCCCN=C(C(CC(=N)O)N=C(C(CC(=O)O)N=C(C(Cc2cnc[nH]2)N=C(C(Cc2ccccc2)N=C(C(C(C)CC)N=C(C(CCCN)N=C1O)O)O)O)O)O)O)O)O)O)O)N.[Zn]

Synonyms:

• Albac
• Bacifarmin
• Bacifarmin-zinc
• Baciferm
• Baciferm PB
• Bacitracin Zinc
• Bacitracin zinc salt
• L-isoleucinamide, N-[[2-(1-amino-2-methylbutyl)-4,5-dihydro-4-thiazolyl]carbonyl]-L-leucyl-D-alpha-glutamyl-N-[(3S,6R,9S,12R,15S,18R,21S)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-6-(carboxymethyl)-9-(1H-imidazol-5-ylmethyl)-15-(1-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-12-(phenylmethyl)-1,4,7,10,13,16,19-heptaazacyclopentacos-21-yl]-, zinc salt (1:1)
• Noptracin
• St 56
• zinc N-{[2-(1-amino-2-methylbutyl)-4,5-dihydro-1,3-thiazol-4-yl]carbonyl}-L-leucyl-5-oxidanidyl-5-oxidanylidene-D-norvalyl-N-{(3S,6R,9S,12R,15S,18R,21S)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-12-benzyl-6-(carboxylatomethyl)-9-(1H-imidazol-5-ylmethyl)-15-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclopentacosan-21-yl}-L-isoleucinamide

BACITRACIN FOR SYSTEM SUITABILITY CRS

CAS: 1405-89-6

BACITRACIN FOR SYSTEM SUITABILITY CRS

Formula: C₆₆H₁₀₃N₁₇O₁₆SZn

Color and Shape: White. Yellow. Powder.

Molecular weight: 1488.101

Ref: 41-Y0001867

SECOND INTERNATIONAL STANDARD FOR BACITRACIN

CAS: 1405-89-6

SECOND INTERNATIONAL STANDARD FOR BACITRACIN

Ref: 41-ISA_62_003

BACITRACIN ZINC CRS

CAS: 1405-89-6

BACITRACIN ZINC CRS

Formula: C₆₆H₁₀₃N₁₇O₁₆SZn

Color and Shape: White. Yellow. Powder.

Molecular weight: 1488.101

Ref: 41-B0100000

Bacitracin Zinc

CAS: 1405-89-6

Antibiotics nesoi

Formula: C₆₆H₁₀₁N₁₇O₁₆SZn(BacitracinAZinc)C₆₅H₉₉N₁₇O₁₆SZn(BacitracinB₁B₂orB₃Zinc)

Color and Shape: White Tan Light Brown Powder

Molecular weight: 1483.66243

Ref: 45-1048007

Bacitracin (zinc)

CAS: 1405-89-6

Formula: C₆₆H₁₀₁N₁₇O₁₆SZn

Color and Shape: Solid

Molecular weight: 1486.0574

Ref: IN-DA001CJR

Bacitracin zinc salt

CAS: 1405-89-6

Formula: C₆₆H₁₀₁N₁₇O₁₆SZn

Purity: ≥ 65.0U/mg (dried basis)

Color and Shape: Off-white to light-yellow powder

Molecular weight: 1486.07

Ref: 7W-GA1078

Bacitracin Zinc

CAS: 1405-89-6

Formula: C₆₆H₁₀₁N₁₇O₁₆S·Zn

Molecular weight: 1420.70 65.38

Ref: 4Z-PB-073022

Bacitracin Zinc

CAS: 1405-89-6

Bacitracin Zinc is a dephosphorylated disruptor of C55-isoprene pyrophosphate that inhibits Tyr cleavage in Met-enkephalin with an IC50 of 10 μM.

Formula: C₆₆H₁₀₁N₁₇O₁₆SZn

Purity: 63.98%

Color and Shape: Light-Colored Free-Flowing Powders

Molecular weight: 1486.07

Ref: TM-T2208

Bacitracin Zinc (>80%)

Controlled Product

CAS: 1405-89-6

Applications Bacitracin is a peptide antibiotic effective against gram-postive bacteria. Bacitracin is an inhibitor of peptidoglycan synthesis. Bacitracin disrupts bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate. Bacitracin also strongly inhibits proline endopeptidase from human muscle.
References Ward, J.B. et al.: Biochem. J., 141, 227 (1974); Anastasi, A. et al.: Biochem. J., 290, 601 (1993); Daly, D.J. et al.: Biochem. Soc. Trans., 13, 1161 (1985); Weinberg, E.D. et al.: Antibiot. Ber., 90, (1967);

Formula: C₆₅H₉₉N₁₇O₁₆S·Zn

Purity: >80%

Color and Shape: Light Yellow To Off-White

Molecular weight: 1472.06

Ref: TR-B106505

Bacitracin zinc

CAS: 1405-89-6

Bacitracin zinc is a biocide that is used for the treatment of infectious diseases in animals. It has neurotrophic and polyvinyl pyrrolidone properties, which inhibit bacterial growth by preventing protein synthesis. Bacitracin zinc can be used to treat infections caused by bacteria that are resistant to penicillin, tetracycline, erythromycin, and other antibiotics. This drug can be formulated as a suspension or an emulsion in a polymeric matrix with undamaged polymer chains to provide stabilization against hydrolysis.

Formula: C₆₆H₁₀₁N₁₇O₁₆SZn

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,486.06 g/mol

Ref: 3D-FB37622