CAS 140678-12-2

U-conotoxin giiib

Description:

U-conotoxin GIIIB is a peptide toxin derived from the venom of marine cone snails, specifically from the species Conus geographus. This compound is classified as a neurotoxin and is known for its ability to selectively block certain types of ion channels, particularly voltage-gated sodium channels. Its mechanism of action involves binding to these channels, which disrupts the normal flow of sodium ions across neuronal membranes, leading to inhibition of neurotransmitter release and modulation of pain pathways. U-conotoxin GIIIB exhibits high specificity and potency, making it a subject of interest in pharmacological research, particularly for its potential applications in pain management and as a tool for studying ion channel function. The structure of U-conotoxin GIIIB consists of a relatively small peptide chain, which contributes to its stability and bioactivity. As with many conotoxins, its unique properties make it a valuable candidate for further investigation in both therapeutic and biochemical contexts.

Formula: C₁₀₁H₁₇₅N₃₉O₃₀S₇

Synonyms:

• Conotoxin GIIIB
• H-Arg-Asp-Cys-Cys-Thr-Hyp-Hyp-Arg-Lys-Cys-Lys-Asp-Arg-Arg-Cys-Lys-Hyp-Met-Lys-Cys-Cys-Ala-NH2 (Disulfide bonds between Cys3 and Cys15/Cys4 and Cys20/ Cys10 and Cys21)
• Mu-Conotoxin Giiib

µ-Conotoxin GIIIB

CAS: 140678-12-2

This strongly basic µ-conotoxin from the venom of Conus geographus is highly effective in blocking sodium channels in vertebrate skeletal muscle, thereby preventing the propagation of muscle action potentials.

Formula: C₁₀₁H₁₇₅N₃₉O₃₀S₇

Purity: 97.2%

Color and Shape: Whitish Powder

Molecular weight: 2640.21

Ref: 01-4016344

µ-Conotoxin GIIIB

CAS: 140678-12-2

μ-Conotoxin GIIIB, a 22-residue polypeptide derived from the venom of the piscivorous cone snail Conus geographus, serves as an inhibitor of the Na V 1.4

Formula: C₁₀₁H₁₇₅N₃₉O₃₀S₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 2640.17

Ref: TM-T80049

µ-conotoxin-GIIIB

CAS: 140678-12-2

Nav1.4 channels

Ref: 3D-PP51156

µ-Conotoxin GIIIB

Controlled Product

CAS: 140678-12-2

The µ-conotoxin GIIIB is a potent nicotinic acetylcholine receptor antagonist and has been shown to inhibit the g1 phase of the cell cycle. It inhibits the binding of veratridine, a neurotoxin, to its receptor on the cell membrane. The µ-conotoxin GIIIB has also been shown to have an inhibitory effect on acetylcholine release from synaptosomes incubated with glucose and insulin. A magnetic resonance spectroscopy (MRS) study showed that µ-conotoxin GIIIB was able to bind to noradrenaline and dopamine receptors in rat erythrocytes. The µ-conotoxin GIIIB is a disulfide bond peptide that can be synthesized by solid-phase synthesis and purified by lc-ms/ms methods. Disulfide bonds are formed between Cys3 and Cys15, Cys4 and Cys20, Cys10

Formula: C₁₀₁H₁₇₅N₃₉O₃₀S₇

Purity: Min. 95%

Molecular weight: 2,640.18 g/mol

Ref: 3D-FC110369