CAS 140712-81-8

3′-O-[Bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-N-(2-methyl-1-oxopropyl)guanosine

Description:

3′-O-[Bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-N-(2-methyl-1-oxopropyl)guanosine, with the CAS number 140712-81-8, is a modified nucleoside derivative of guanosine. This compound features a guanine base linked to a deoxyribose sugar, which is further substituted at the 3′ position with a bis(4-methoxyphenyl)phenylmethyl group. The presence of the methoxy groups enhances the lipophilicity and potentially the biological activity of the molecule. The N-(2-methyl-1-oxopropyl) substitution at the guanine base introduces additional steric and electronic properties, which may influence its interaction with biological targets, such as enzymes or receptors. This compound is of interest in medicinal chemistry and biochemistry due to its potential applications in drug development, particularly in the context of nucleoside analogs that can modulate nucleic acid functions. Its structural complexity suggests that it may exhibit unique pharmacological properties, warranting further investigation into its biological activity and therapeutic potential.

Formula: C₃₅H₃₇N₅O₇

InChI: InChI=1S/C35H37N5O7/c1-21(2)32(42)38-34-37-31-30(33(43)39-34)36-20-40(31)29-18-27(28(19-41)46-29)47-35(22-8-6-5-7-9-22,23-10-14-25(44-3)15-11-23)24-12-16-26(45-4)17-13-24/h5-17,20-21,27-29,41H,18-19H2,1-4H3,(H2,37,38,39,42,43)/t27-,28+,29+/m0/s1

InChI key: InChIKey=FRMKNQDKTCCNED-ZGIBFIJWSA-N

SMILES: C(O[C@@H]1[C@@H](CO)O[C@H](C1)N2C3=C(N=C2)C(=O)N=C(NC(C(C)C)=O)N3)(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6

Synonyms:

• 2′-Deoxy-3′-O-(dimethoxytrityl)-N-isobutyrylguanosine
• Guanosine, 3′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-N-(2-methyl-1-oxopropyl)-
• 3′-O-[Bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-N-(2-methyl-1-oxopropyl)guanosine

N-(9-((2R,4S,5R)-4-(Bis(4-methoxyphenyl)(phenyl)methoxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

CAS: 140712-81-8

N-(9-((2R,4S,5R)-4-(Bis(4-methoxyphenyl)(phenyl)methoxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Purity: 98%

Molecular weight: 639.71g/mol

Ref: 54-OR1061328

2'-Deoxy-3'-O-DMT-N2-Isobutyrylguanosine

CAS: 140712-81-8

2'-Deoxy-3'-O-DMT-N2-Isobutyrylguanosine is a synthetic nucleoside that has the ability to activate and inhibit the growth of cancer cells. This compound is a phosphoramidite, and it has been modified by the addition of an isobutyrate group at the 2' position. The structure of this nucleoside is similar to that of natural guanosine, but with an additional 2' oxygen atom. This modification can be used for inhibition of DNA synthesis in cells and may have antiviral effects.

Formula: C₃₅H₃₇N₅O₇

Purity: Min. 97 Area-%

Molecular weight: 639.71 g/mol

Ref: 3D-ND06928

2'-Deoxy-3'-O-DMT-N2-isobutyrylguanosine

Controlled Product

CAS: 140712-81-8

Formula: C₃₅H₃₇N₅O₇

Color and Shape: Neat

Molecular weight: 639.698

Ref: TR-D232993