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CAS 140712-83-0

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Cytidine, N-benzoyl-3′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-, 5′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

Description:
Cytidine, N-benzoyl-3′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-, 5′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is a synthetic nucleoside derivative used primarily in the field of molecular biology and biochemistry, particularly in the synthesis of oligonucleotides. This compound features a cytidine base, which is a nucleoside composed of a pyrimidine base (cytosine) and a ribose sugar, modified with a benzoyl group and a phosphoramidite moiety. The presence of the 3′-O-benzoyl and 5′-cyanoethyl phosphoramidite groups enhances its stability and reactivity, making it suitable for automated DNA synthesis. The bis(4-methoxyphenyl)phenylmethyl substituent contributes to its hydrophobic characteristics, potentially influencing solubility and interaction with other biomolecules. This compound is typically handled under controlled conditions due to its reactivity and is utilized in research applications involving gene synthesis, molecular cloning, and the development of therapeutic oligonucleotides. Proper safety measures should be observed when working with this substance due to its chemical properties.
Formula:C46H52N5O8P
InChI:InChI=1S/C46H52N5O8P/c1-32(2)51(33(3)4)60(56-29-13-27-47)57-31-41-40(30-43(58-41)50-28-26-42(49-45(50)53)48-44(52)34-14-9-7-10-15-34)59-46(35-16-11-8-12-17-35,36-18-22-38(54-5)23-19-36)37-20-24-39(55-6)25-21-37/h7-12,14-26,28,32-33,40-41,43H,13,29-31H2,1-6H3,(H,48,49,52,53)/t40-,41+,43+,60?/m0/s1
InChI key:InChIKey=OXUQZHDIUOKQGM-SALLYJDFSA-N
SMILES:C(O[C@@H]1[C@@H](COP(N(C(C)C)C(C)C)OCCC#N)O[C@H](C1)N2C(=O)N=C(NC(=O)C3=CC=CC=C3)C=C2)(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6
Synonyms:
  • N4-Benzoyl-3'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-5'-cyanoethyl Phosphoramidite
  • Cytidine, N-benzoyl-3′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-, 5′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
  • Cytidine, N-benzoyl-3′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-, 5′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • DMT-dC(Bz)-5'-CE Reverse Phosphoramidite
  • N4-Benzoyl-2'-deoxy-3'-O-DMT-cytidine 5'-CE phosphoramidite
  • (N4-BENZOYL)-5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYCYTIDINE
  • N4-Bz-3’-O-DMTr-2’-deoxycytidine 5’-O-CE-phosphoramidite
  • DMT-dC(Bz)-CE Reverse Phosphoramidite
  • (N4-Benzoyl)-5'-O-[(N,N-diisopropylamino)(2-cyanoethoxy)phoshinyl}-3'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine
  • Cytidine,N-benzoyl-3'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 5'-[2-cyanoethylbis(1-methylethyl)phosphoramidite] (9CI)
  • See more synonyms
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