CAS 140896-21-5

indolicidin

Description:

Indolicidin is a peptide composed of 13 amino acids, primarily known for its antimicrobial properties. It is derived from the indole-containing amino acid tryptophan and exhibits a unique structure that contributes to its biological activity. Indolicidin is characterized by its ability to disrupt bacterial membranes, making it effective against a range of Gram-positive and Gram-negative bacteria, as well as some fungi. The peptide's mechanism of action involves binding to the lipid bilayer of microbial cells, leading to membrane destabilization and cell lysis. Additionally, indolicidin has been studied for its potential applications in therapeutic settings, particularly in combating antibiotic-resistant infections. Its stability and efficacy in various environments make it a subject of interest in the field of antimicrobial research. However, further studies are needed to fully understand its pharmacokinetics, toxicity, and potential side effects in clinical applications. Overall, indolicidin represents a promising avenue for the development of new antimicrobial agents.

Formula: C₁₀₀H₁₃₂N₂₆O₁₃

InChI: InChI=1/C100H132N26O13/c1-5-57(4)85(102)95(136)123-79(45-56(2)3)96(137)124-42-20-36-82(124)92(133)118-76(46-58-51-110-68-28-11-6-23-63(58)68)89(130)116-74(33-16-17-39-101)88(129)121-80(49-61-54-113-71-31-14-9-26-66(61)71)97(138)125-43-21-38-84(125)94(135)120-78(48-60-53-112-70-30-13-8-25-65(60)70)91(132)122-81(50-62-55-114-72-32-15-10-27-67(62)72)98(139)126-44-22-37-83(126)93(134)119-77(47-59-52-111-69-29-12-7-24-64(59)69)90(131)117-75(35-19-41-109-100(106)107)87(128)115-73(86(103)127)34-18-40-108-99(104)105/h6-15,23-32,51-57,73-85,110-114H,5,16-22,33-50,101-102H2,1-4H3,(H2,103,127)(H,115,128)(H,116,130)(H,117,131)(H,118,133)(H,119,134)(H,120,135)(H,121,129)(H,122,132)(H,123,136)(H4,104,105,108)(H4,106,107,109)/t57-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-/m0/s1

SMILES: CC[C@H](C)[C@@H](C(=N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=N[C@@H](Cc1c[nH]c2ccccc12)C(=N[C@@H](CCCCN)C(=N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=N[C@@H](Cc1c[nH]c2ccccc12)C(=N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=N[C@@H](Cc1c[nH]c2ccccc12)C(=N[C@@H](CCCNC(=N)N)C(=N[C@@H](CCCNC(=N)N)C(=N)O)O)O)O)O)O)O)O)O)O)N

Synonyms:

• H-Ile-Leu-Pro-Trp-Lys-Trp-Pro-Trp-Trp-Pro-Trp-Arg-Arg-NH2

Indolicidin

CAS: 140896-21-5

For cellular and molecular biology applications

Color and Shape: Lyophilized Powder, White

Ref: 02-J65215

Indolicidin

CAS: 140896-21-5

This cationic, tryptophan-rich peptide was purified from bovine granulocytes. Indolicidin shows potent antimicrobial activity in vitro against bacteria and fungi. It is also highly cytotoxic to T-line cells.

Formula: C₁₀₀H₁₃₂N₂₆O₁₃

Purity: > 96%

Color and Shape: Whitish Powder

Molecular weight: 1906.32

Ref: 01-4030762

Indolicidin

CAS: 140896-21-5

Formula: C₁₀₀H₁₃₂N₂₆O₁₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 1906.2845

Ref: IN-DA01CPAF

Indolicidin

CAS: 140896-21-5

Indolicidin

Purity: ≥98%

Molecular weight: 1906.28g/mol

Ref: 54-BUP05374

Indolicidin

CAS: 140896-21-5

Indolicidin: 13-amino acid peptide, highest tryptophan content, carboxamidated C-terminal arginine.

Formula: C₁₀₀H₁₃₂N₂₆O₁₃

Purity: >99.99%

Color and Shape: Solid

Molecular weight: 1906.28

Ref: TM-TP1319

Indolicidin TFA Salt

Controlled Product

CAS: 140896-21-5

Applications Indolicidin is an antimicrobial peptide containing multiple tryptophan residues.

Formula: C₁₀₀H₁₃₂N₂₆O₁₃•x(C₂HF₃O₂)

Color and Shape: Neat

Molecular weight: 1906.2811402

Ref: TR-I627273