CAS 141-90-2

Thiouracil

Description:

Thiouracil is an organic compound classified as a thioketone and is structurally related to uracil, differing by the presence of a sulfur atom in place of the oxygen atom at the carbonyl position. It appears as a white to off-white crystalline solid and is soluble in water and alcohol. Thiouracil is primarily known for its role as an antithyroid agent, used in the treatment of hyperthyroidism by inhibiting the synthesis of thyroid hormones. Its mechanism of action involves the interference with the incorporation of iodine into thyroglobulin, thereby reducing hormone production. Additionally, thiouracil has applications in biochemistry and pharmacology, particularly in studies related to nucleic acids and enzyme inhibition. The compound has a relatively low toxicity profile, but it can cause side effects such as skin rashes and gastrointestinal disturbances. As with many pharmaceuticals, its use should be monitored by healthcare professionals to mitigate potential adverse effects and interactions with other medications.

Formula: C₄H₄N₂OS

InChI: InChI=1S/C4H4N2OS/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)

InChI key: InChIKey=ZEMGGZBWXRYJHK-UHFFFAOYSA-N

SMILES: O=C1NC(=S)NC=C1

Synonyms:

• 2,3-Dihydro-2-Thioxo-4(1H)-Pyrimidino
• 2,3-Dihydro-2-thioxo-4(1H)-pyrimidinone
• 2-Mercapto-3H-pyrimidin-4-one
• 2-Mercapto-4-hydroxypyrimidine
• 2-Mercapto-4-pyrimidinol
• 2-Mercapto-4-pyrimidinone
• 2-Sulfanyl-3,4-dihydropyrimidin-4-one
• 2-Sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one
• 2-Sulfanylidene-1H-pyrimidin-4-one
• 2-Sulfanylpyrimidin-4-ol
• 2-Thiouracile
• 2-Thioxo-2,3-dihydro-1H-pyrimidin-4-one
• 2-Thioxo-2,3-dihydropyrimidin-4(1H)-one
• 2-Tiouracilo
• 4(1H)-Pyrimidinone, 2,3-dihydro-2-thioxo-
• 4-Hydroxy-2-Mercaptopyrimidine
• 4-Hydroxy-2-pyrimidinethiol
• 6-Hydroxy-2-mercaptopyrimidine
• Antagothyroil
• Deracil
• Nobilen
• Nsc 19473
• Nsc 290412
• Nsc 290413
• Nsc 290414
• Thiouracil

2-Thiouracil

CAS: 141-90-2

Formula: C₄H₄N₂OS

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 128.15

Ref: 3B-T0224

2-Thiouracil

CAS: 141-90-2

Color and Shape: Neat

Ref: 61-FOR3270.00

4(1H)-Pyrimidinone, 2,3-dihydro-2-thioxo-

CAS: 141-90-2

Formula: C₄H₄N₂OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 128.1524

Ref: IN-DA001FQ6

2-Thiouracil

CAS: 141-90-2

2-Thiouracil (Deracil) is a thiolated uracil derivative that is a known anti-hyperthyroid agent.

Formula: C₄H₄N₂OS

Purity: 99.89%

Color and Shape: Minute Crystals Prisms Or White Or Pale Cream-Colored Powder White To Pale Yellow Crystalline Powder

Molecular weight: 128.15

Ref: TM-T1310

2-Thiouracil

CAS: 141-90-2

2-Thiouracil

Formula: C₄H₄N₂OS

Purity: 99%

Color and Shape: off-white powder

Molecular weight: 128.15g/mol

Ref: 54-OR350373

2-Thiouracil

CAS: 141-90-2

Formula: C₄H₄N₂OS

Purity: ≥ 98.0%

Color and Shape: White to light-yellow crystalline powder

Molecular weight: 128.15

Ref: 7W-GK3183

2-Thiouracil

CAS: 141-90-2

2-Thiouracil

Purity: ≥98%

Molecular weight: 128.15g/mol

Ref: 54-BUP19586

2-Thiouracil

CAS: 141-90-2

Formula: C₄H₄N₂OS

Color and Shape: Neat

Molecular weight: 128.15

Ref: 04-C17561500

2-Thiouracil

CAS: 141-90-2

Formula: C₄H₄N₂OS

Color and Shape: Neat

Molecular weight: 128.15

Ref: 86-MM3270.00

Thiouracil-13C,15N2

Controlled Product

CAS: 141-90-2

Applications Thiouracil-13C,15N2 is the labelled version of 2-Thiouracil (T375400), which is a reagent used in the preparation of Antithyroid agents.
References Toropov, A., et al.: Eur. J. Med. Chem., 45, 3581 (2010), Daniels, C., et al.: J. Bacteriol., 192, 2169 (2010), Castillo-Garit, J., et al.: Eur. J. Pharm. Sci., 39, 30 (2010),

Formula: CC₃H₄₁₅N₂OS

Color and Shape: Neat

Molecular weight: 131.13

Ref: TR-T375408

2-Thiouracil

CAS: 141-90-2

Applications Reagent used in the preparation of Antithyroid agents.
References Toropov, A., et al.: Eur. J. Med. Chem., 45, 3581 (2010), Daniels, C., et al>.: J. Bacteriol., 192, 2169 (2010), Castillo-Garit, J., et al.: Eur. J. Pharm. Sci., 39, 30 (2010),

Formula: C₄H₄N₂OS

Color and Shape: Colourless

Molecular weight: 128.15

Ref: TR-T375400

2-Thiouracil

CAS: 141-90-2

2-Thiouracil is a photochemical that reacts with DNA by intermolecular hydrogen bonding, leading to DNA strand breakage. The reaction mechanism of 2-thiouracil has been elucidated through in vitro assays, which showed that the drug binds to the major groove of DNA duplexes and causes cleavage in the region containing two nitrogen atoms.

Formula: C₄H₄N₂OS

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 128.15 g/mol

Ref: 3D-FT02604

2-Thiouracil

CAS: 141-90-2

2-Thiouracil is a versatile building block and useful intermediate in organic synthesis. It is also used as a reagent in the preparation of various other compounds, such as thiourea, 2-aminoethanethiol, and sulfhydryl. 2-Thiouracil has been shown to have antibacterial properties against staphylococci and streptococci in vitro.

Formula: C₄H₄N₂OS

Purity: Min. 98.0 Area-%

Molecular weight: 128.15 g/mol

Ref: 3D-T-3800

2-Thiouracil

CAS: 141-90-2

Please enquire for more information about 2-Thiouracil including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₄H₄N₂OS

Purity: Min. 98.0 Area-%

Molecular weight: 128.15 g/mol

Ref: 3D-T-3801

2-Thiouracil

CAS: 141-90-2

Formula: C₄H₄N₂OS

Purity: 97%

Color and Shape: Solid

Molecular weight: 128.15

Ref: 10-F078506

2-Thiouracil extrapure, 98%

CAS: 141-90-2

Formula: C₄H₄N₂OS

Purity: min. 98%

Color and Shape: Pale yellow, Powder, Clear

Molecular weight: 128.15

Ref: SR-96768