3',5'-Di-O-acetyl-5-fluoro-O4-(2,4,6-trimethylphenyl)-2'-deoxyuridine is a modified nucleoside analog that exhibits unique structural and chemical characteristics. This compound features a deoxyuridine backbone, which is a nucleoside composed of a sugar (deoxyribose) and a nitrogenous base (uracil), with specific acetyl and fluoro substitutions that enhance its biological activity. The presence of the 5-fluoro group is significant as it can influence the compound's interaction with nucleic acid synthesis and its potential as an antiviral or anticancer agent. The O-acetyl groups contribute to the compound's lipophilicity, potentially affecting its cellular uptake and stability. The bulky 2,4,6-trimethylphenyl group may also impact the compound's binding affinity to target enzymes or receptors. Overall, this compound's unique modifications suggest potential applications in medicinal chemistry, particularly in the development of therapeutics targeting viral infections or cancer, although further studies would be necessary to fully elucidate its pharmacological properties and mechanisms of action.

3',5'-DI-O-ACETYL-5-FLUORO-O4-(2,4,6-TRIMETHYLPHENYL)-2'-DEOXYURIDINE

141120-62-9: 3',5'-Di-O-acetyl-5-fluoro-O4-(2,4,6-trimethylphenyl)-2'-deoxyuridine is a modified nucleoside analog that exhibits unique structural and chemical characteristics. This compound features a deoxyuridine backbone, which is a nucleoside composed of a sugar (deoxyribose) and a nitrogenous base (uracil), with specific acetyl and fluoro substitutions that enhance its biological activity. The presence of the 5-fluoro group is significant as it can influence the compound's interaction with nucleic acid synthesis and its potential as an antiviral or anticancer agent. The O-acetyl groups contribute to the compound's lipophilicity, potentially affecting its cellular uptake and stability. The bulky 2,4,6-trimethylphenyl group may also impact the compound's binding affinity to target enzymes or receptors. Overall, this compound's unique modifications suggest potential applications in medicinal chemistry, particularly in the development of therapeutics targeting viral infections or cancer, although further studies would be necessary to fully elucidate its pharmacological properties and mechanisms of action.

<p>3,5-Di-o-acetyl-5-fluoro-O4-(2,4,6-trimethylphenyl)-2-deoxyuridine is a novel modified monophosphate nucleoside. It is an antiviral agent and has been shown to have anticancer activity. 3,5-Di-o-acetyl-5-fluoro-O4-(2,4,6-trimethylphenyl)-2-deoxyuridine is synthesized by the reaction of 5'-triphosphates with 2'-deoxyribonucleosides in the presence of a phosphoramidite. This nucleoside has been found to be cytotoxic in vitro and in vivo against cancer cell lines and can be used as a therapeutic agent for the treatment of leukemia.</p>

CAS 141120-62-9

3',5'-DI-O-ACETYL-5-FLUORO-O4-(2,4,6-TRIMETHYLPHENYL)-2'-DEOXYURIDINE

3,5-Di-o-acetyl-5-fluoro-O4-(2,4,6-trimethylphenyl)-2-deoxyuridine

Ref: 3D-RFA12062