CAS 141200-24-0: Darglitazone

Description: Darglitazone is a synthetic compound belonging to the thiazolidinedione class of drugs, primarily utilized for its potential role in the management of type 2 diabetes mellitus. It acts as a selective agonist for peroxisome proliferator-activated receptor gamma (PPAR-γ), which plays a crucial role in glucose and lipid metabolism. Darglitazone is characterized by its ability to enhance insulin sensitivity, thereby improving glycemic control in diabetic patients. The compound exhibits anti-inflammatory properties and may influence adipocyte differentiation and lipid storage. Its chemical structure includes a thiazolidinedione moiety, which is essential for its biological activity. Darglitazone has been studied for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, although specific details may vary. As with other thiazolidinediones, potential side effects may include weight gain and fluid retention, necessitating careful patient monitoring. Overall, Darglitazone represents a promising therapeutic option in diabetes management, although its clinical use may be subject to regulatory approval and ongoing research.

Formula: C₂₃H₂₀N₂O₄S

InChI: InChI=1S/C23H20N2O4S/c1-14-18(24-22(29-14)17-5-3-2-4-6-17)11-12-19(26)16-9-7-15(8-10-16)13-20-21(27)25-23(28)30-20/h2-10,20H,11-13H2,1H3,(H,25,27,28)

InChI key: InChIKey=QQKNSPHAFATFNQ-UHFFFAOYSA-N

SMILES: O=C1SC(C(=O)N1)CC2=CC=C(C=C2)C(=O)CCC=3N=C(OC3C)C=4C=CC=CC4

Synonyms:

• (±)-5-[p-[3-(5-Methyl-2-phenyl-4-oxazolyl)propionyl]benzyl]-2,4-thiazolidinedione
• 2,4-Thiazolidinedione, 5-((4-(3-(5-methyl-2-phenyl-4-oxazolyl)-1-oxopropyl)phenyl)methyl)-, (+-)-
• 5-[[4-[3-(5-Methyl-2-phenyl-4-oxazolyl)-1-oxopropyl]phenyl]methyl]-2,4-thiazolidinedione
• 5-{4-[3-(5-Methyl-2-Phenyl-1,3-Oxazol-4-Yl)Propanoyl]Benzyl}-1,3-Thiazolidine-2,4-Dione
• Cp 86325
• Darglitazone [INN]
• Unii-Avp9C03Z3K
• Darglitazone
• Darglitazone

Darglitazone

CAS: 141200-24-0

Darglitazone is a type of antidiabetic agent that belongs to the thiazolidinedione class. It is …

• Formula: C₂₃H₂₀N₂O₄S
• Purity: Min. 95%
• Molecular weight: 420.5 g/mol

Darglitazone

CAS: 141200-24-0

Darglitazone (CP-86325) is a potent, selective agonist of PPAR-γ with antidiabetic actions.

• Formula: C₂₃H₂₀N₂O₄S
• Purity: 99.19%
• Color and Shape: Solid
• Molecular weight: 420.48