CAS 141200-24-0

Darglitazone

Description:

Darglitazone is a synthetic compound belonging to the thiazolidinedione class of drugs, primarily utilized for its potential role in the management of type 2 diabetes mellitus. It acts as a selective agonist for peroxisome proliferator-activated receptor gamma (PPAR-γ), which plays a crucial role in glucose and lipid metabolism. Darglitazone is characterized by its ability to enhance insulin sensitivity, thereby improving glycemic control in diabetic patients. The compound exhibits anti-inflammatory properties and may influence adipocyte differentiation and lipid storage. Its chemical structure includes a thiazolidinedione moiety, which is essential for its biological activity. Darglitazone has been studied for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, although specific details may vary. As with other thiazolidinediones, potential side effects may include weight gain and fluid retention, necessitating careful patient monitoring. Overall, Darglitazone represents a promising therapeutic option in diabetes management, although its clinical use may be subject to regulatory approval and ongoing research.

Formula: C₂₃H₂₀N₂O₄S

InChI: InChI=1S/C23H20N2O4S/c1-14-18(24-22(29-14)17-5-3-2-4-6-17)11-12-19(26)16-9-7-15(8-10-16)13-20-21(27)25-23(28)30-20/h2-10,20H,11-13H2,1H3,(H,25,27,28)

InChI key: InChIKey=QQKNSPHAFATFNQ-UHFFFAOYSA-N

SMILES: C(CC(=O)C1=CC=C(CC2SC(=O)NC2=O)C=C1)C=3N=C(OC3C)C4=CC=CC=C4

Synonyms:

• (±)-5-[p-[3-(5-Methyl-2-phenyl-4-oxazolyl)propionyl]benzyl]-2,4-thiazolidinedione
• 2,4-Thiazolidinedione, 5-((4-(3-(5-methyl-2-phenyl-4-oxazolyl)-1-oxopropyl)phenyl)methyl)-, (+-)-
• 5-[[4-[3-(5-Methyl-2-phenyl-4-oxazolyl)-1-oxopropyl]phenyl]methyl]-2,4-thiazolidinedione
• 5-{4-[3-(5-Methyl-2-Phenyl-1,3-Oxazol-4-Yl)Propanoyl]Benzyl}-1,3-Thiazolidine-2,4-Dione
• Cp 86325
• Darglitazone [INN]
• Unii-Avp9C03Z3K
• Darglitazone
• Darglitazone

Darglitazone

CAS: 141200-24-0

Darglitazone

Purity: ≥98%

Molecular weight: 420.48g/mol

Ref: 54-BUP14372

Darglitazone

CAS: 141200-24-0

Darglitazone is a type of antidiabetic agent that belongs to the thiazolidinedione class. It is used in the treatment of type II diabetes, which is characterized by high blood glucose levels as a result of insulin resistance. Darglitazone has been shown to bind to human fatty acid receptors and activate these receptors, thereby increasing glucose uptake into cells and reducing hepatic glucose production. This drug also has metabolic effects in non-human animals, including an increase in nitrogen-containing compounds such as urea and creatinine. Darglitazone also activates transcription-polymerase chain reaction (PCR) activity on du145 cells in culture. Although the mechanism is not yet fully understood, it may be due to its ability to inhibit protein synthesis or to activate gene expression of proteins involved in the insulin signalling pathway.

Formula: C₂₃H₂₀N₂O₄S

Purity: Min. 95%

Molecular weight: 420.5 g/mol

Ref: 3D-RFA20024

Darglitazone

CAS: 141200-24-0

Darglitazone (CP-86325) is a potent, selective agonist of PPAR-γ with antidiabetic actions.

Formula: C₂₃H₂₀N₂O₄S

Purity: 99.76%

Color and Shape: Solid

Molecular weight: 420.48

Ref: TM-T22708