CAS 141505-33-1
:Levosimendan
Description:
Levosimendan is a pharmacological agent primarily used in the treatment of acute heart failure. It is classified as a calcium sensitizer, which enhances cardiac contractility without significantly increasing myocardial oxygen demand. This unique mechanism of action distinguishes it from traditional inotropic agents. Levosimendan also possesses vasodilatory properties, which help reduce preload and afterload on the heart, further improving cardiac output. The substance is characterized by its ability to stabilize the troponin complex, leading to increased calcium sensitivity in cardiac myocytes. Its chemical structure includes a chiral center, resulting in the presence of enantiomers, with the (R)-enantiomer being the active form. Levosimendan is typically administered intravenously and has a relatively short half-life, necessitating careful monitoring during treatment. Common side effects may include hypotension, headache, and gastrointestinal disturbances. Overall, Levosimendan represents a valuable therapeutic option in managing acute decompensated heart failure, particularly in patients who may not tolerate conventional therapies.
Formula:C14H12N6O
InChI:InChI=1S/C14H12N6O/c1-9-6-13(21)19-20-14(9)10-2-4-11(5-3-10)17-18-12(7-15)8-16/h2-5,9,17H,6H2,1H3,(H,19,21)/t9-/m1/s1
InChI key:InChIKey=WHXMKTBCFHIYNQ-SECBINFHSA-N
SMILES:C[C@H]1C(C2=CC=C(NN=C(C#N)C#N)C=C2)=NNC(=O)C1
Synonyms:- (R)-((4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazono) propanedintrile
- Mesoxalonitrile (p-((R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-pyridazinyl)phenyl)hydrazone
- Simdax
- Propanedinitrile, [[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]-, (R)-
- Levosimendan [INN]
- ((4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazono)propanedinitrile
- Propanedinitrile, [[4-[(4R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazono]-
- ({4-[(4R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl]phenyl}hydrazono)propanedinitrile
- 2-[2-[4-[(4R)-1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazinylidene]propanedinitrile
- (R)-((4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazono)propanedinitrile
- Mesoxalonitrile (-)-(p((R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazone
- Levosimendan
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Found 12 products.
Levosimendan
CAS:Formula:C14H12N6OPurity:>98.0%(HPLC)Color and Shape:Light yellow to Brown powder to crystalMolecular weight:280.29Levosimendan
CAS:Formula:C14H12N6OPurity:≥ 98.0%Color and Shape:Light yellow to yellow powderMolecular weight:280.28Levosimendan
CAS:<p>Levosimendan (OR1259) is a calcium sensitizer for acute heart failure, enhancing cardiac contractility without raising calcium levels.</p>Formula:C14H12N6OPurity:99.37% - 99.91%Color and Shape:Yellow Crystalline PowderMolecular weight:280.28Levosimendan
CAS:<p>Applications Bioactive enantiomer of racemate, Simendan. Positive inotropic agent with vasodilating activity. Cardiotonic.<br>References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995), Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996),<br></p>Formula:C14H12N6OColor and Shape:Yellow To Dark YellowMolecular weight:280.28Levosimendan
CAS:<p>Inodilator; calcium sensitizer; ATP-dependent potassium channel opener</p>Formula:C14H12N6OPurity:Min. 95%Color and Shape:Yellow PowderMolecular weight:280.28 g/molLevosimendan - Bio-X ™
CAS:<p>Levosimendan has been shown to act as a calcium sensitiser and increase cytosolic Ca2+ levels. It is an analog of the cardiac glycoside, ouabain. This drug has been shown to be effective for the treatment of congestive heart failure and is used to increase the heart’s contractility and decrease its rate in patients who have low cardiac output. Levosimendan also causes vasodilation by increasing nitric oxide production in vascular endothelial cells.</p>Formula:C14H12N6OPurity:Min. 95%Color and Shape:PowderMolecular weight:280.28 g/mol
