CAS 141625-93-6
:Dronedarone hydrochloride
Description:
Dronedarone hydrochloride is a pharmaceutical compound primarily used in the management of atrial fibrillation and atrial flutter, conditions characterized by irregular heartbeats. It is classified as an antiarrhythmic agent and is structurally related to amiodarone, although it has a more favorable side effect profile. The substance is a white to off-white crystalline powder that is soluble in water and exhibits a moderate lipophilicity. Dronedarone functions by blocking various ion channels, including sodium, potassium, and calcium channels, which helps to stabilize the cardiac rhythm. Its pharmacokinetics involve extensive hepatic metabolism, primarily via cytochrome P450 enzymes, and it has a relatively short half-life compared to amiodarone. The hydrochloride salt form enhances its solubility and bioavailability. Common side effects may include gastrointestinal disturbances, liver enzyme elevations, and potential cardiovascular effects, necessitating careful monitoring during treatment. Overall, Dronedarone hydrochloride represents an important therapeutic option for patients with specific cardiac arrhythmias.
Formula:C31H45ClN2O5S
InChI:InChI=1/C31H44N2O5S.ClH/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3;/h13-18,23,32H,5-12,19-22H2,1-4H3;1H
SMILES:CCCCc1c(c2cc(ccc2o1)NS(=O)(=O)C)C(=O)c1ccc(cc1)OCCCN(CCCC)CCCC.Cl
Synonyms:- Dronedarone HCl
- N-(2-butyl-3-{4-[3-(dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl)methanesulfonamide hydrochloride (1:1)
- Dronedarone Intermediate 1
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 15 products.
Dronedarone Hydrochloride
CAS:Formula:C31H44N2O5S·HClPurity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:593.22Dronedarone Hydrochloride
CAS:Sulfonamides used as drugsFormula:C31H44N2O5S·HClColor and Shape:PowderMolecular weight:592.27377Methanesulfonamide, N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]-, hydrochloride (1:1)
CAS:Formula:C31H45ClN2O5SPurity:95%Color and Shape:SolidMolecular weight:593.2174Dronedarone hydrochloride
CAS:Dronedarone hydrochloride (SR33589) is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.Formula:C31H44N2O5S·HClPurity:99.61%Color and Shape:SolidMolecular weight:593.22Dronedarone hydrochloride
CAS:Formula:C31H44N2O5S·HClPurity:(Titration) ≥ 98.0% (dried basis)Color and Shape:White to off-white powderMolecular weight:593.22Dronedarone HCl
CAS:Formula:C31H44N2O5S·HClColor and Shape:White To Off-White SolidMolecular weight:556.76 36.46Dronedarone Hydrochloride
CAS:<p>Stability Hygroscopic<br>Applications A drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.<br>References Singh, B., et al.: J. Cardiovas. Pharmacol., 52, 300 (2008), Hoy, S., et al.: Drugs, 69, 1647 (2009), Hohnloser, S., et al.: New Eng. J. Med., 360, 668 (2009),<br></p>Formula:C31H44N2O5S·ClHColor and Shape:NeatMolecular weight:593.22Dronedarone hydrochloride
CAS:<p>Multichannel blocker; reduces sodium and calcium currents</p>Formula:C31H44N2O5S•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:593.22 g/molDronedarone HCl - Bio-X ™
CAS:<p>Dronedarone is a novel class III anti-arrhythmic drug. It has been shown to be effective in the treatment of atrial fibrillation and congestive heart failure. Dronedarone is a multi-channel blocker that achieves heart rate and rhythm control in atrial fibrillation. Additonally, Dronedarone decreases arterial blood pressure and reduces oxygen consumption. It inhibits sodium currents rate-dependently and blocks slow calcium inward currents.</p>Formula:C31H44N2O5S•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:593.22 g/mol
![Methanesulfonamide, N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]-, hydrochlor…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA001GOO.jpg&w=3840&q=75)
